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FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)

Identity

Alias_namesFERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Alias_symbol (synonym)CDEP
PLEKHC2
MGC87400
PPP1R75
Other aliasFARP1-IT1
HGNC (Hugo) FARP1
LocusID (NCBI) 10160
Atlas_Id 43253
Location 13q32.2  [Link to chromosome band 13q32]
Location_base_pair Starts at 98143098 and ends at 98449773 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CADM2 (3p12.1) / FARP1 (13q32.2)CHST11 (12q23.3) / FARP1 (13q32.2)CLMP (11q24.1) / FARP1 (13q32.2)
FARP1 (13q32.2) / DKK3 (11p15.3)FARP1 (13q32.2) / FARP1 (13q32.2)FARP1 (13q32.2) / GPC6 (13q31.3)
FARP1 (13q32.2) / NALCN (13q33.1)FARP1 (13q32.2) / NME1-NME2 (17q21.33)FARP1 (13q32.2) / RERE (1p36.23)
FARP1 (13q32.2) / SIAE (11q24.2)FARP1 (13q32.2) / STK24 (13q32.2)FARP1 (13q32.2) / SYN1 (Xp11.23)
FARP1 (13q32.2) / UCHL3 (13q22.2)NECTIN1 (11q23.3) / FARP1 (13q32.2)TUBGCP3 (13q34) / FARP1 (13q32.2)
XXYLT1 (3q29) / FARP1 (13q32.2)FARP1 13q32.2 / GPC6 13q31.3FARP1 13q32.2 / NALCN 13q33.1
FARP1 13q32.2 / NME1-NME2 17q21.33FARP1 13q32.2 / SIAE 11q24.2FARP1 13q32.2 / UCHL3 13q22.2
TUBGCP3 13q34 / FARP1 13q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(11;13)(q24;q32) FARP1/SIAE
t(13;13)(q22;q32) FARP1/UCHL3
t(13;13)(q31;q32) FARP1/GPC6
t(13;13)(q32;q33) FARP1/NALCN
t(13;13)(q32;q34) TUBGCP3/FARP1
t(13;17)(q32;q21) FARP1/NME1-NME2

External links

Nomenclature
HGNC (Hugo)FARP1   3591
Cards
Entrez_Gene (NCBI)FARP1  10160  FERM, ARH/RhoGEF and pleckstrin domain protein 1
AliasesCDEP; FARP1-IT1; PLEKHC2; PPP1R75
GeneCards (Weizmann)FARP1
Ensembl hg19 (Hinxton)ENSG00000152767 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152767 [Gene_View]  ENSG00000152767 [Sequence]  chr13:98143098-98449773 [Contig_View]  FARP1 [Vega]
ICGC DataPortalENSG00000152767
TCGA cBioPortalFARP1
AceView (NCBI)FARP1
Genatlas (Paris)FARP1
WikiGenes10160
SOURCE (Princeton)FARP1
Genetics Home Reference (NIH)FARP1
Genomic and cartography
GoldenPath hg38 (UCSC)FARP1  -     chr13:98143098-98449773 +  13q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FARP1  -     13q32.2   [Description]    (hg19-Feb_2009)
GoldenPathFARP1 - 13q32.2 [CytoView hg19]  FARP1 - 13q32.2 [CytoView hg38]
ImmunoBaseENSG00000152767
Mapping of homologs : NCBIFARP1 [Mapview hg19]  FARP1 [Mapview hg38]
OMIM602654   
Gene and transcription
Genbank (Entrez)AB008430 AI273567 AI274149 AI381545 AK095747
RefSeq transcript (Entrez)NM_001001715 NM_001286839 NM_005766
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FARP1
Cluster EST : UnigeneHs.729583 [ NCBI ]
CGAP (NCI)Hs.729583
Alternative Splicing GalleryENSG00000152767
Gene ExpressionFARP1 [ NCBI-GEO ]   FARP1 [ EBI - ARRAY_EXPRESS ]   FARP1 [ SEEK ]   FARP1 [ MEM ]
Gene Expression Viewer (FireBrowse)FARP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10160
GTEX Portal (Tissue expression)FARP1
Human Protein AtlasENSG00000152767-FARP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4F1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4F1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4F1
Splice isoforms : SwissVarQ9Y4F1
PhosPhoSitePlusQ9Y4F1
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    FERM_1 (PS00660)    FERM_3 (PS50057)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Band_41_domain    DBL_dom_sf    DH-domain    Ez/rad/moesin-like    FERM-adjacent    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PH-like_dom_sf    PH_domain    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)FA (PF08736)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam08736    pfam09380    pfam00373    pfam09379    pfam00169    pfam00621   
Domain families : Smart (EMBL)B41 (SM00295)  FA (SM01195)  FERM_C (SM01196)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FARP1
DMDM Disease mutations10160
Blocks (Seattle)FARP1
PDB (RSDB)4H6Y   
PDB Europe4H6Y   
PDB (PDBSum)4H6Y   
PDB (IMB)4H6Y   
Structural Biology KnowledgeBase4H6Y   
SCOP (Structural Classification of Proteins)4H6Y   
CATH (Classification of proteins structures)4H6Y   
SuperfamilyQ9Y4F1
Human Protein Atlas [tissue]ENSG00000152767-FARP1 [tissue]
Peptide AtlasQ9Y4F1
IPIIPI00024773   IPI00746455   IPI00418590   IPI01018855   IPI00553014   IPI00552839   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4F1
IntAct (EBI)Q9Y4F1
FunCoupENSG00000152767
BioGRIDFARP1
STRING (EMBL)FARP1
ZODIACFARP1
Ontologies - Pathways
QuickGOQ9Y4F1
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  cytosol  cytoskeleton  synapse assembly  cytoskeletal protein binding  negative regulation of phosphatase activity  cell junction  filopodium  dendrite  Rac guanyl-nucleotide exchange factor activity  Rac guanyl-nucleotide exchange factor activity  extrinsic component of cytoplasmic side of plasma membrane  regulation of Rho protein signal transduction  dendritic spine  dendrite morphogenesis  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  cytosol  cytoskeleton  synapse assembly  cytoskeletal protein binding  negative regulation of phosphatase activity  cell junction  filopodium  dendrite  Rac guanyl-nucleotide exchange factor activity  Rac guanyl-nucleotide exchange factor activity  extrinsic component of cytoplasmic side of plasma membrane  regulation of Rho protein signal transduction  dendritic spine  dendrite morphogenesis  
NDEx NetworkFARP1
Atlas of Cancer Signalling NetworkFARP1
Wikipedia pathwaysFARP1
Orthology - Evolution
OrthoDB10160
GeneTree (enSembl)ENSG00000152767
Phylogenetic Trees/Animal Genes : TreeFamFARP1
HOGENOMQ9Y4F1
Homologs : HomoloGeneFARP1
Homology/Alignments : Family Browser (UCSC)FARP1
Gene fusions - Rearrangements
Fusion : MitelmanFARP1/GPC6 [13q32.2/13q31.3]  
Fusion : MitelmanFARP1/NALCN [13q32.2/13q33.1]  [t(13;13)(q32;q33)]  
Fusion : MitelmanFARP1/NME1-NME2 [13q32.2/17q21.33]  [t(13;17)(q32;q21)]  
Fusion : MitelmanFARP1/SIAE [13q32.2/11q24.2]  [t(11;13)(q24;q32)]  
Fusion : MitelmanFARP1/UCHL3 [13q32.2/13q22.2]  [t(13;13)(q22;q32)]  
Fusion : MitelmanTUBGCP3/FARP1 [13q34/13q32.2]  [t(13;13)(q32;q34)]  
Fusion PortalFARP1 13q32.2 GPC6 13q31.3 LUSC
Fusion PortalFARP1 13q32.2 NALCN 13q33.1 LUAD
Fusion PortalFARP1 13q32.2 NME1-NME2 17q21.33 LGG
Fusion PortalFARP1 13q32.2 SIAE 11q24.2 BRCA
Fusion PortalFARP1 13q32.2 UCHL3 13q22.2 LUAD
Fusion PortalTUBGCP3 13q34 FARP1 13q32.2 BRCA
Fusion : QuiverFARP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFARP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FARP1
dbVarFARP1
ClinVarFARP1
1000_GenomesFARP1 
Exome Variant ServerFARP1
ExAC (Exome Aggregation Consortium)ENSG00000152767
GNOMAD BrowserENSG00000152767
Varsome BrowserFARP1
Genetic variants : HAPMAP10160
Genomic Variants (DGV)FARP1 [DGVbeta]
DECIPHERFARP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFARP1 
Mutations
ICGC Data PortalFARP1 
TCGA Data PortalFARP1 
Broad Tumor PortalFARP1
OASIS PortalFARP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFARP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFARP1
Mutations and Diseases : HGMDFARP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FARP1
DgiDB (Drug Gene Interaction Database)FARP1
DoCM (Curated mutations)FARP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FARP1 (select a term)
intoGenFARP1
Cancer3DFARP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602654   
Orphanet
DisGeNETFARP1
MedgenFARP1
Genetic Testing Registry FARP1
NextProtQ9Y4F1 [Medical]
TSGene10160
GENETestsFARP1
Target ValidationFARP1
Huge Navigator FARP1 [HugePedia]
snp3D : Map Gene to Disease10160
BioCentury BCIQFARP1
ClinGenFARP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10160
Chemical/Pharm GKB GenePA28004
Clinical trialFARP1
Miscellaneous
canSAR (ICR)FARP1 (select the gene name)
DataMed IndexFARP1
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFARP1
EVEXFARP1
GoPubMedFARP1
iHOPFARP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:42:55 CET 2019
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