Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FASLG (Fas ligand)

Identity

Alias_namesAPT1LG1
TNFSF6
tumor necrosis factor (ligand) superfamily, member 6
Fas ligand (TNF superfamily, member 6)
Alias_symbol (synonym)FasL
CD178
Other aliasALPS1B
APTL
CD95-L
CD95L
FASL
TNLG1A
HGNC (Hugo) FASLG
LocusID (NCBI) 356
Atlas_Id 396
Location 1q24.3  [Link to chromosome band 1q24]
Location_base_pair Starts at 172659008 and ends at 172666872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRRC2C (1q24.3) / FASLG (1q24.3)PRRC2C 1q24.3 / FASLG 1q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PRRC2C/FASLG (1q24)

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Autoimmune lymphoproliferative syndrome

External links

Nomenclature
HGNC (Hugo)FASLG   11936
LRG (Locus Reference Genomic)LRG_58
Cards
Entrez_Gene (NCBI)FASLG  356  Fas ligand
AliasesALPS1B; APT1LG1; APTL; CD178; 
CD95-L; CD95L; FASL; TNFSF6; TNLG1A
GeneCards (Weizmann)FASLG
Ensembl hg19 (Hinxton)ENSG00000117560 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117560 [Gene_View]  ENSG00000117560 [Sequence]  chr1:172659008-172666872 [Contig_View]  FASLG [Vega]
ICGC DataPortalENSG00000117560
TCGA cBioPortalFASLG
AceView (NCBI)FASLG
Genatlas (Paris)FASLG
WikiGenes356
SOURCE (Princeton)FASLG
Genetics Home Reference (NIH)FASLG
Genomic and cartography
GoldenPath hg38 (UCSC)FASLG  -     chr1:172659008-172666872 +  1q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FASLG  -     1q24.3   [Description]    (hg19-Feb_2009)
GoldenPathFASLG - 1q24.3 [CytoView hg19]  FASLG - 1q24.3 [CytoView hg38]
ImmunoBaseENSG00000117560
Mapping of homologs : NCBIFASLG [Mapview hg19]  FASLG [Mapview hg38]
OMIM134638   211980   601859   
Gene and transcription
Genbank (Entrez)AF288573 AK314874 AY225406 AY858799 BC017502
RefSeq transcript (Entrez)NM_000639 NM_001302746
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FASLG
Cluster EST : UnigeneHs.2007 [ NCBI ]
CGAP (NCI)Hs.2007
Alternative Splicing GalleryENSG00000117560
Gene ExpressionFASLG [ NCBI-GEO ]   FASLG [ EBI - ARRAY_EXPRESS ]   FASLG [ SEEK ]   FASLG [ MEM ]
Gene Expression Viewer (FireBrowse)FASLG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)356
GTEX Portal (Tissue expression)FASLG
Human Protein AtlasENSG00000117560-FASLG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48023   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48023  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48023
Splice isoforms : SwissVarP48023
PhosPhoSitePlusP48023
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)FASL    TNF    TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)FASLG
DMDM Disease mutations356
Blocks (Seattle)FASLG
PDB (RSDB)1BZI    4MSV    5L19    5L36   
PDB Europe1BZI    4MSV    5L19    5L36   
PDB (PDBSum)1BZI    4MSV    5L19    5L36   
PDB (IMB)1BZI    4MSV    5L19    5L36   
Structural Biology KnowledgeBase1BZI    4MSV    5L19    5L36   
SCOP (Structural Classification of Proteins)1BZI    4MSV    5L19    5L36   
CATH (Classification of proteins structures)1BZI    4MSV    5L19    5L36   
SuperfamilyP48023
Human Protein Atlas [tissue]ENSG00000117560-FASLG [tissue]
Peptide AtlasP48023
HPRD00610
IPIIPI00007577   IPI00220870   
Protein Interaction databases
DIP (DOE-UCLA)P48023
IntAct (EBI)P48023
FunCoupENSG00000117560
BioGRIDFASLG
STRING (EMBL)FASLG
ZODIACFASLG
Ontologies - Pathways
QuickGOP48023
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  signaling receptor binding  death receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  integral component of plasma membrane  caveola  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cytokine-mediated signaling pathway  cellular chloride ion homeostasis  response to lipopolysaccharide  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic vesicle lumen  extracellular exosome  T cell apoptotic process  necroptotic process  response to growth factor  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  release of sequestered calcium ion into cytosol by endoplasmic reticulum  positive regulation of endothelial cell apoptotic process  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  signaling receptor binding  death receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  integral component of plasma membrane  caveola  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cytokine-mediated signaling pathway  cellular chloride ion homeostasis  response to lipopolysaccharide  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic vesicle lumen  extracellular exosome  T cell apoptotic process  necroptotic process  response to growth factor  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  release of sequestered calcium ion into cytosol by endoplasmic reticulum  positive regulation of endothelial cell apoptotic process  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Cytokine-cytokine receptor interaction    FoxO signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    Neurotrophin signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Pathways in cancer    Proteoglycans in cancer    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease   
NDEx NetworkFASLG
Atlas of Cancer Signalling NetworkFASLG
Wikipedia pathwaysFASLG
Orthology - Evolution
OrthoDB356
GeneTree (enSembl)ENSG00000117560
Phylogenetic Trees/Animal Genes : TreeFamFASLG
HOGENOMP48023
Homologs : HomoloGeneFASLG
Homology/Alignments : Family Browser (UCSC)FASLG
Gene fusions - Rearrangements
Fusion : MitelmanPRRC2C/FASLG [1q24.3/1q24.3]  [t(1;1)(q24;q24)]  
Fusion PortalPRRC2C 1q24.3 FASLG 1q24.3 BRCA
Fusion : QuiverFASLG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFASLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FASLG
dbVarFASLG
ClinVarFASLG
1000_GenomesFASLG 
Exome Variant ServerFASLG
ExAC (Exome Aggregation Consortium)ENSG00000117560
GNOMAD BrowserENSG00000117560
Varsome BrowserFASLG
Genetic variants : HAPMAP356
Genomic Variants (DGV)FASLG [DGVbeta]
DECIPHERFASLG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFASLG 
Mutations
ICGC Data PortalFASLG 
TCGA Data PortalFASLG 
Broad Tumor PortalFASLG
OASIS PortalFASLG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFASLG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFASLG
Mutations and Diseases : HGMDFASLG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch FASLG
DgiDB (Drug Gene Interaction Database)FASLG
DoCM (Curated mutations)FASLG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FASLG (select a term)
intoGenFASLG
Cancer3DFASLG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134638    211980    601859   
Orphanet3468   
DisGeNETFASLG
MedgenFASLG
Genetic Testing Registry FASLG
NextProtP48023 [Medical]
TSGene356
GENETestsFASLG
Target ValidationFASLG
Huge Navigator FASLG [HugePedia]
snp3D : Map Gene to Disease356
BioCentury BCIQFASLG
ClinGenFASLG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD356
Chemical/Pharm GKB GenePA56
Clinical trialFASLG
Miscellaneous
canSAR (ICR)FASLG (select the gene name)
DataMed IndexFASLG
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFASLG
EVEXFASLG
GoPubMedFASLG
iHOPFASLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:42:55 CET 2019
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