FASLG (Fas ligand)

2005-02-01 Affiliation

Identity

HGNC

FASLG

LOCATION

1q24.3

LOCUSID

356

ALIAS

ALPS1B,APT1LG1,APTL,CD178,CD95-L,CD95L,FASL,TNFSF6,TNLG1A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 356
MIM: 134638
HGNC: 11936
Ensembl: ENSG00000117560

Variants:

dbSNP: 356
ClinVar: 356
TCGA: ENSG00000117560
COSMIC: FASLG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117560	ENST00000340030	P48023
ENSG00000117560	ENST00000367721	P48023
ENSG00000117560	ENST00000367721	Q53ZZ1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Cytokine-cytokine receptor interaction	KEGG	ko04060
Apoptosis	KEGG	ko04210
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Type I diabetes mellitus	KEGG	ko04940
Autoimmune thyroid disease	KEGG	ko05320
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
MAPK signaling pathway	KEGG	hsa04010
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Apoptosis	KEGG	hsa04210
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Type I diabetes mellitus	KEGG	hsa04940
Pathways in cancer	KEGG	hsa05200
Autoimmune thyroid disease	KEGG	hsa05320
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Ras signaling pathway	KEGG	hsa04014
FoxO signaling pathway	KEGG	hsa04068
Disease	REACTOME	R-HSA-1643685
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034
Signal Transduction	REACTOME	R-HSA-162582
Death Receptor Signalling	REACTOME	R-HSA-73887
FasL/ CD95L signaling	REACTOME	R-HSA-75157
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathway	REACTOME	R-HSA-5357769
Ligand-dependent caspase activation	REACTOME	R-HSA-140534
Dimerization of procaspase-8	REACTOME	R-HSA-69416
Regulation by c-FLIP	REACTOME	R-HSA-3371378
Regulated Necrosis	REACTOME	R-HSA-5218859
RIPK1-mediated regulated necrosis	REACTOME	R-HSA-5213460
Regulation of necroptotic cell death	REACTOME	R-HSA-5675482
CASP8 activity is inhibited	REACTOME	R-HSA-5218900
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Neurodegenerative Diseases	REACTOME	R-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	REACTOME	R-HSA-8862803
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12021310	2002	Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.	212
16081306	2005	Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis.	108
12414525	2002	Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.	98
12637505	2003	Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.	97
15272306	2004	CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells.	84
14739003	2004	Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses.	65
19155494	2009	Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis.	64
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23177026	2013	The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL.	61
11739488	2001	Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells.	60

Citation

Dessen P

FASLG (Fas ligand)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/396/faslg