FASTK (Fas activated serine/threonine kinase)

2006-10-01  

Identity

HGNC
FASTK
LOCATION
7q36.1
LOCUSID
10922
ALIAS
FAST

Other Information

Locus ID:

NCBI: 10922
MIM: 606965
HGNC: 24676
Ensembl: ENSG00000164896

Variants:

dbSNP: 10922
ClinVar: 10922
TCGA: ENSG00000164896
COSMIC: FASTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164896ENST00000297532Q14296
ENSG00000164896ENST00000297532A0A090N8Z7
ENSG00000164896ENST00000353841Q14296
ENSG00000164896ENST00000353841A0A090N8I0
ENSG00000164896ENST00000482571Q14296
ENSG00000164896ENST00000540185G3V1R6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
171352692007Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.37
257048142015A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.25
155726762004FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.24
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
240135842013miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.17
175921272007Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.16
203639722010Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.5

Citation

Dessen P

FASTK (Fas activated serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43254/fastk