FBP2 (fructose-bisphosphatase 2)

2007-04-01  

Identity

HGNC
LOCATION
9q22.32
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8789
MIM: 603027
HGNC: 3607
Ensembl: ENSG00000130957

Variants:

dbSNP: 8789
ClinVar: 8789
TCGA: ENSG00000130957
COSMIC: FBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130957ENST00000375337O00757

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Fructose and mannose metabolismKEGGko00051
Insulin signaling pathwayKEGGko04910
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Fructose and mannose metabolismKEGGhsa00051
Insulin signaling pathwayKEGGhsa04910
Metabolic pathwaysKEGGhsa01100
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240635582013Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells.17
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
182149672008Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.8
244125652014Changes in quaternary structure of muscle fructose-1,6-bisphosphatase regulate affinity of the enzyme to mitochondria.7
162134872005The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP.4
312802692019MicroRNA-591 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Lowering Drug Resistance through Inhibition of Far-Upstream Element-Binding Protein 2-Mediated Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Axis.2

Citation

Dessen P

FBP2 (fructose-bisphosphatase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47210/fbp2