FBXL12 (F-box and leucine rich repeat protein 12)

2007-04-01  

Identity

HGNC
FBXL12
LOCATION
19p13.2
LOCUSID
54850
ALIAS
Fbl12

Other Information

Locus ID:

NCBI: 54850
MIM: 609079
HGNC: 13611
Ensembl: ENSG00000127452

Variants:

dbSNP: 54850
ClinVar: 54850
TCGA: ENSG00000127452
COSMIC: FBXL12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127452ENST00000247977Q9NXK8
ENSG00000127452ENST00000585379Q9NXK8
ENSG00000127452ENST00000586073K7EK37
ENSG00000127452ENST00000586469K7EQJ7
ENSG00000127452ENST00000586651K7EPT3
ENSG00000127452ENST00000588922K7EQY7
ENSG00000127452ENST00000589438K7EPT3
ENSG00000127452ENST00000589626K7EIR3
ENSG00000127452ENST00000590277K7EPN7
ENSG00000127452ENST00000590808K7ELM5
ENSG00000127452ENST00000591009Q9NXK8
ENSG00000127452ENST00000592067K7EIK3
ENSG00000127452ENST00000592732K7ESL6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
237073882013Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.7
261240792015FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.5
272153842016SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.2

Citation

Dessen P

FBXL12 (F-box and leucine rich repeat protein 12)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46954/fbxl12