FBXL17 (F-box and leucine rich repeat protein 17)

2008-12-01  

Identity

HGNC
LOCATION
5q21.3
LOCUSID
ALIAS
FBXO13,Fbl17,Fbx13
FUSION GENES

Other Information

Locus ID:

NCBI: 64839
MIM: 609083
HGNC: 13615
Ensembl: ENSG00000145743

Variants:

dbSNP: 64839
ClinVar: 64839
TCGA: ENSG00000145743
COSMIC: FBXL17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145743ENST00000496714Q9UF56
ENSG00000145743ENST00000542267Q9UF56
ENSG00000145743ENST00000619412H7C835

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240354982013Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.42
272342982016SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.12
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
188203692008Identification of F-box/LLR-repeated protein 17 as potential useful biomarker for breast cancer therapy.6

Citation

Dessen P

FBXL17 (F-box and leucine rich repeat protein 17)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50499/fbxl17