FBXL18 (F-box and leucine rich repeat protein 18)

2012-11-01  

Identity

HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
Fbl18
FUSION GENES

Other Information

Locus ID:

NCBI: 80028
MIM: 609084
HGNC: 21874
Ensembl: ENSG00000155034

Variants:

dbSNP: 80028
ClinVar: 80028
TCGA: ENSG00000155034
COSMIC: FBXL18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155034ENST00000382368Q96ME1
ENSG00000155034ENST00000382368A0A024R857
ENSG00000155034ENST00000415009Q96ME1
ENSG00000155034ENST00000453700Q96ME1
ENSG00000155034ENST00000458142H0Y6I6
ENSG00000155034ENST00000620087Q96D16

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
FBXL7 down-regulates AURKA during mitotic entry and in early mitosisREACTOMER-HSA-8854050

References

Pubmed IDYearTitleCitations
256547632015F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.16
279269902017The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.6
278907082017Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.0

Citation

Dessen P

FBXL18 (F-box and leucine rich repeat protein 18)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52999/fbxl18