FBXL2 (F-box and leucine rich repeat protein 2)

2012-09-01  

Identity

HGNC
FBXL2
LOCATION
3p22.3
LOCUSID
25827
ALIAS
FBL2,FBL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25827
MIM: 605652
HGNC: 13598
Ensembl: ENSG00000153558

Variants:

dbSNP: 25827
ClinVar: 25827
TCGA: ENSG00000153558
COSMIC: FBXL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153558ENST00000421391F8WE99
ENSG00000153558ENST00000422741F8WC58
ENSG00000153558ENST00000425973F8WB01
ENSG00000153558ENST00000432809F8WBW7
ENSG00000153558ENST00000435207F8WBS9
ENSG00000153558ENST00000451636F8WCQ8
ENSG00000153558ENST00000484457Q9UKC9
ENSG00000153558ENST00000538892Q9UKC9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
236043172013FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.46
286143002017PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.46
260379282015Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.38
223234462012F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.35
220203282012F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.31
223997572012FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.22
267906402016F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1.8
224559802013Neuronal expression of F-box and leucine-rich-repeat protein 2 decreases over Braak stages in the brains of Alzheimer's disease patients.3
319531622020MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.2

Citation

Dessen P

FBXL2 (F-box and leucine rich repeat protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52859/fbxl2