FBXL22 (F-box and leucine rich repeat protein 22)

2013-02-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
Fbl22

Other Information

Locus ID:

NCBI: 283807
MIM: 609088
HGNC: 27537
Ensembl: ENSG00000197361

Variants:

dbSNP: 283807
ClinVar: 283807
TCGA: ENSG00000197361
COSMIC: FBXL22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197361ENST00000360587Q6P050
ENSG00000197361ENST00000534939H0YMQ4
ENSG00000197361ENST00000560325R4GNI3
ENSG00000197361ENST00000638704A0A1W2PQW8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
229728772012F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.0

Citation

Dessen P

FBXL22 (F-box and leucine rich repeat protein 22)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53188/fbxl22