FBXL5 (F-box and leucine rich repeat protein 5)

2015-02-01 Affiliation

Identity

HGNC

FBXL5

LOCATION

4p15.32

LOCUSID

26234

ALIAS

FBL4,FBL5,FLR1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26234
MIM: 605655
HGNC: 13602
Ensembl: ENSG00000118564

Variants:

dbSNP: 26234
ClinVar: 26234
TCGA: ENSG00000118564
COSMIC: FBXL5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118564	ENST00000341285	Q9UKA1
ENSG00000118564	ENST00000412094	Q9UKA1
ENSG00000118564	ENST00000503196	D6RCR7
ENSG00000118564	ENST00000507899	D6R9Y4
ENSG00000118564	ENST00000509314	D6RHC3
ENSG00000118564	ENST00000510802	D6RBW7
ENSG00000118564	ENST00000511441	D6RED6
ENSG00000118564	ENST00000512066	H0YAG2
ENSG00000118564	ENST00000513163	H0Y9Y0
ENSG00000118564	ENST00000515679	D6RB50

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Association of TriC/CCT with target proteins during biosynthesis	REACTOME	R-HSA-390471
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

References

Pubmed ID	Year	Title	Citations
19762596	2009	Control of iron homeostasis by an iron-regulated ubiquitin ligase.	158
19762597	2009	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.	146
22253436	2012	Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).	29
25832584	2015	FBXL5 inhibits metastasis of gastric cancer through suppressing Snail1.	19
23135277	2013	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	16
22648410	2012	Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.	15
24778179	2014	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	12
25956243	2015	FBXL5 modulates HIF-1α transcriptional activity by degradation of CITED2.	11
17532294	2007	FBXL5 interacts with p150Glued and regulates its ubiquitination.	10
28714470	2017	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.	9

Citation

Dessen P

FBXL5 (F-box and leucine rich repeat protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55008/fbxl5