FBXO2 (F-box protein 2)

2016-10-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
FBG1,FBX2,Fbs1,NFB42,OCP1
FUSION GENES

Other Information

Locus ID:

NCBI: 26232
MIM: 607112
HGNC: 13581
Ensembl: ENSG00000116661

Variants:

dbSNP: 26232
ClinVar: 26232
TCGA: ENSG00000116661
COSMIC: FBXO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116661ENST00000354287Q9UK22
ENSG00000116661ENST00000465901R4GNH2
ENSG00000116661ENST00000642025A0A286YF37

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
SCF-FBS complexKEGGhsa_M00382
SCF-FBS complexKEGGM00382
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
277568462016SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.12
129045742003Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway.11
264606112015The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.6
283419772017Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.6
211355782010FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest.5
274879262016Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase.5
285344822017An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides.5
292693012018FBXO2, a novel marker for metastasis in human gastric cancer.5
262953392015FBG1 Is the Final Arbitrator of A1AT-Z Degradation.0

Citation

Dessen P

FBXO2 (F-box protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56334/fbxo2