FBXO21 (F-box protein 21)

2014-11-01  

Identity

HGNC
FBXO21
LOCATION
12q24.22
LOCUSID
23014
ALIAS
FBX21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23014
MIM: 609095
HGNC: 13592
Ensembl: ENSG00000135108

Variants:

dbSNP: 23014
ClinVar: 23014
TCGA: ENSG00000135108
COSMIC: FBXO21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135108ENST00000330622O94952
ENSG00000135108ENST00000330622A0A024RBR2
ENSG00000135108ENST00000427718Q4G104
ENSG00000135108ENST00000548840H0YHF6
ENSG00000135108ENST00000550180H0YIE9
ENSG00000135108ENST00000622495O94952
ENSG00000135108ENST00000622495A0A024RBL8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseVariantAnnotationnot associatedPD29938344
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD29938344
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD29938344

References

Pubmed IDYearTitleCitations
262996182015CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.7
266317462015Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.3
260853302015FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.2

Citation

Dessen P

FBXO21 (F-box protein 21)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63325/fbxo21