FBXO22 (F-box protein 22)

2016-10-01  

Identity

HGNC
LOCATION
15q24.2
LOCUSID
ALIAS
FBX22,FISTC1
FUSION GENES

Other Information

Locus ID:

NCBI: 26263
MIM: 609096
HGNC: 13593
Ensembl: ENSG00000167196

Variants:

dbSNP: 26263
ClinVar: 26263
TCGA: ENSG00000167196
COSMIC: FBXO22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167196ENST00000308275Q8NEZ5
ENSG00000167196ENST00000453211Q8NEZ5
ENSG00000167196ENST00000561885H3BVA4
ENSG00000167196ENST00000564220H3BTR7
ENSG00000167196ENST00000565036H3BTH6
ENSG00000167196ENST00000569022Q8NEZ5
ENSG00000167196ENST00000569054H3BUC1
ENSG00000167196ENST00000569749H3BRE0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
217683092011SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.45
268681482016SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.31
227615742012GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1.28
299459592018FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression.19
260871832015F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.17
304181742018Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.11
281176752017F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.8
308083762019FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21.7
253366572014FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.6
311386832019SCFFBXO22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis.2

Citation

Dessen P

FBXO22 (F-box protein 22)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56035/fbxo22