FBXO25 (F-box protein 25)

2007-04-01  

Identity

HGNC
FBXO25
LOCATION
8p23.3
LOCUSID
26260
ALIAS
FBX25
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26260
MIM: 609098
HGNC: 13596
Ensembl: ENSG00000147364

Variants:

dbSNP: 26260
ClinVar: 26260
TCGA: ENSG00000147364
COSMIC: FBXO25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147364ENST00000276326Q8TCJ0
ENSG00000147364ENST00000350302Q8TCJ0
ENSG00000147364ENST00000350302A0A024QZ88
ENSG00000147364ENST00000352684Q8TCJ0
ENSG00000147364ENST00000382824Q8TCJ0
ENSG00000147364ENST00000518240E5RFH9
ENSG00000147364ENST00000519274H0YBS4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068

References

Pubmed IDYearTitleCitations
254197092014Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.12
215960192011A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.9
182875342008FBXO25-associated nuclear domains: a novel subnuclear structure.6
239400302013The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein.5
162780472006Characterization of FBX25, encoding a novel brain-expressed F-box protein.4
275961422016FBXO25 promotes cell proliferation, invasion, and migration of NSCLC.3
283892972017FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation.3
204739702010Identification of FBXO25-interacting proteins using an integrated proteomics approach.2

Citation

Dessen P

FBXO25 (F-box protein 25)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47354/fbxo25