FBXO27 (F-box protein 27)

2014-11-01  

Identity

HGNC
FBXO27
LOCATION
19q13.2
LOCUSID
126433
ALIAS
FBG5,Fbx27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 126433
MIM: 609099
HGNC: 18753
Ensembl: ENSG00000161243

Variants:

dbSNP: 126433
ClinVar: 126433
TCGA: ENSG00000161243
COSMIC: FBXO27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161243ENST00000292853Q8NI29
ENSG00000161243ENST00000292853A0A384MR61
ENSG00000161243ENST00000509137Q8NI29
ENSG00000161243ENST00000509137A0A384MR61
ENSG00000161243ENST00000593847M0R1C3
ENSG00000161243ENST00000598394M0R0I8
ENSG00000161243ENST00000600828M0QYQ6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
287437552017Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.15

Citation

Dessen P

FBXO27 (F-box protein 27)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63329/fbxo27