FBXO28 (F-box protein 28)

2013-11-01  

Identity

HGNC
LOCATION
1q42.11
LOCUSID
ALIAS
CENP-30,Fbx28
FUSION GENES

Other Information

Locus ID:

NCBI: 23219
MIM: 609100
HGNC: 29046
Ensembl: ENSG00000143756

Variants:

dbSNP: 23219
ClinVar: 23219
TCGA: ENSG00000143756
COSMIC: FBXO28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143756ENST00000366862Q9NVF7
ENSG00000143756ENST00000366862A0A024R3Q6
ENSG00000143756ENST00000424254Q9NVF7
ENSG00000143756ENST00000523990B4E0H5

Expression (GTEx)

0
5
10
15
20
25
30
35

References

Pubmed IDYearTitleCitations
237761312013CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.26
243570762014Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures.8
277547532016Fbxo28 promotes mitotic progression and regulates topoisomerase IIα-dependent DNA decatenation.4
281795882017TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.3
295873692018An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis.0
301608312018A novel FBXO28 frameshift mutation in a child with developmental delay, dysmorphic features, and intractable epilepsy: A second gene that may contribute to the 1q41-q42 deletion phenotype.0

Citation

Dessen P

FBXO28 (F-box protein 28)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53564/fbxo28