FBXO3 (F-box protein 3)

2014-08-01  

Identity

HGNC
FBXO3
LOCATION
11p13
LOCUSID
26273
ALIAS
FBA,FBX3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26273
MIM: 609089
HGNC: 13582
Ensembl: ENSG00000110429

Variants:

dbSNP: 26273
ClinVar: 26273
TCGA: ENSG00000110429
COSMIC: FBXO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110429ENST00000265651Q9UK99
ENSG00000110429ENST00000448981Q9UK99
ENSG00000110429ENST00000526785G3V1E0
ENSG00000110429ENST00000529137E9PL46
ENSG00000110429ENST00000530401Q9UK99
ENSG00000110429ENST00000531080Q49AF1
ENSG00000110429ENST00000532057Q49AF1
ENSG00000110429ENST00000532927B4E3U2
ENSG00000110429ENST00000534136E9PJM3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
235427412013A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
244035782014Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.29
188095792008PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.27
257216642015F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.8
273653982016FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).6
301710692018The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.2
270108662016Crystal structure and interaction studies of the human FBxo3 ApaG domain.0
304484802019The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis.0

Citation

Dessen P

FBXO3 (F-box protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54315/fbxo3