FBXO32 (F-box protein 32)

2007-04-01  

Identity

HGNC
LOCATION
8q24.13
LOCUSID
ALIAS
Fbx32,MAFbx
FUSION GENES

Other Information

Locus ID:

NCBI: 114907
MIM: 606604
HGNC: 16731
Ensembl: ENSG00000156804

Variants:

dbSNP: 114907
ClinVar: 114907
TCGA: ENSG00000156804
COSMIC: FBXO32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156804ENST00000443022Q969P5
ENSG00000156804ENST00000517956Q969P5
ENSG00000156804ENST00000517956A0A024R9F3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
250961802014Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.180
179011162007The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse.89
179922592007The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.84
228150452013Atrogin-1, MuRF-1, and sarcopenia.63
174786212007Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.61
165077682006Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1.47
208338242011Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse.44
200659492010Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.41
198505792010Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.39
176092552007Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle.37

Citation

Dessen P

FBXO32 (F-box protein 32)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46698/fbxo32