FBXO44 (F-box protein 44)

2014-11-01  

Identity

HGNC
FBXO44
LOCATION
1p36.22
LOCUSID
93611
ALIAS
FBG3,FBX30,FBX6A,Fbx44,Fbxo6a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 93611
MIM: 609111
HGNC: 24847
Ensembl: ENSG00000132879

Variants:

dbSNP: 93611
ClinVar: 93611
TCGA: ENSG00000132879
COSMIC: FBXO44

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132879ENST00000251546Q9H4M3
ENSG00000132879ENST00000251546A0A024R4J6
ENSG00000132879ENST00000251547Q9H4M3
ENSG00000132879ENST00000251547A0A024R4F9
ENSG00000132879ENST00000376760Q9H4M3
ENSG00000132879ENST00000376760A0A024R4J6
ENSG00000132879ENST00000376762Q9H4M3
ENSG00000132879ENST00000376762A0A024R4J6
ENSG00000132879ENST00000376768B7Z1P2
ENSG00000132879ENST00000376770Q9H4M3
ENSG00000132879ENST00000376770A0A024R4F9
ENSG00000132879ENST00000425796A0A0A0MSI6
ENSG00000132879ENST00000471895R4GNH4
ENSG00000132879ENST00000475435R4GMZ8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
230869372012The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.18
259706262015FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.7
264606112015The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.6
200570812010Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.2

Citation

Dessen P

FBXO44 (F-box protein 44)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63334/fbxo44