FBXO46 (F-box protein 46)

2007-04-01  

Identity

HGNC
FBXO46
LOCATION
19q13.32
LOCUSID
23403
ALIAS
20D7-FC4,FBXO34L,Fbx46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23403
MIM: 609117
HGNC: 25069
Ensembl: ENSG00000177051

Variants:

dbSNP: 23403
ClinVar: 23403
TCGA: ENSG00000177051
COSMIC: FBXO46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177051ENST00000317683Q6PJ61
ENSG00000177051ENST00000586899K7ERN4
ENSG00000177051ENST00000591686K7EKF1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
301710692018The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.2

Citation

Dessen P

FBXO46 (F-box protein 46)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47311/fbxo46