FBXO5 (F-box protein 5)

2008-08-01  

Identity

HGNC
LOCATION
6q25.2
LOCUSID
ALIAS
EMI1,FBX5,Fbxo31

Other Information

Locus ID:

NCBI: 26271
MIM: 606013
HGNC: 13584
Ensembl: ENSG00000112029

Variants:

dbSNP: 26271
ClinVar: 26271
TCGA: ENSG00000112029
COSMIC: FBXO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112029ENST00000229758Q9UKT4
ENSG00000112029ENST00000367241Q9UKT4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
G1/S-Specific TranscriptionREACTOMER-HSA-69205
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic Metaphase/Anaphase TransitionREACTOMER-HSA-68881
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Phosphorylation of Emi1REACTOMER-HSA-176417
SCF-beta-TrCP mediated degradation of Emi1REACTOMER-HSA-174113

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371214102023Exploring the role of FBXO5 in gastric cancer.1
371680482023Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.1
380410322023Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells.0
371214102023Exploring the role of FBXO5 in gastric cancer.1
371680482023Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.1
380410322023Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells.0
357203272022Prognostic Significance and Immunological Role of FBXO5 in Human Cancers: A Systematic Pan-Cancer Analysis.3
357203272022Prognostic Significance and Immunological Role of FBXO5 in Human Cancers: A Systematic Pan-Cancer Analysis.3
334125592021Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.10
337857362021PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.5
334125592021Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.10
337857362021PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.5
303412462019Prognostic values of F-box members in breast cancer: an online database analysis and literature review.19
305549482019The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.46
310366962019Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/C(CDH1) Activity and Pharmacologic Inhibition of APC/C(CDH1/CDC20) Compromises Viability.20

Citation

Dessen P

FBXO5 (F-box protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50287/fbxo5