FBXO6 (F-box protein 6)

2007-04-01  

Identity

HGNC
FBXO6
LOCATION
1p36.22
LOCUSID
26270
ALIAS
FBG2,FBS2,FBX6,Fbx6b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26270
MIM: 605647
HGNC: 13585
Ensembl: ENSG00000116663

Variants:

dbSNP: 26270
ClinVar: 26270
TCGA: ENSG00000116663
COSMIC: FBXO6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116663ENST00000376753Q9NRD1
ENSG00000116663ENST00000449067J3KQ72

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
SCF-FBS complexKEGGhsa_M00382
SCF-FBS complexKEGGM00382
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197167892009The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.81
129392782003Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.48
222687292012Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.13
222920782012SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.8
278554032016FBXO6-Mediated Ubiquitination and Degradation of Ero1L Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis.8
253743772014FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.5
311405862019Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.2
305262522018Overexpression of Fbxo6 inactivates spindle checkpoint by interacting with Mad2 and BubR1.1
313080892019Noncanonical Role of FBXO6 in Regulating Antiviral Immunity.1

Citation

Dessen P

FBXO6 (F-box protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46885/fbxo6