FBXW2 (F-box and WD repeat domain containing 2)

2007-04-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
FBW2,Fwd2,Md6
FUSION GENES

Other Information

Locus ID:

NCBI: 26190
MIM: 609071
HGNC: 13608
Ensembl: ENSG00000119402

Variants:

dbSNP: 26190
ClinVar: 26190
TCGA: ENSG00000119402
COSMIC: FBXW2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119402ENST00000453291Q4VXH1
ENSG00000119402ENST00000608872Q9UKT8

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
280900882017The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.24
156405262005FBW2 targets GCMa to the ubiquitin-proteasome degradation system.23
187034172008Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.10
236510622013RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.7
309182502019FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation.5
315483782019The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells.5

Citation

Dessen P

FBXW2 (F-box and WD repeat domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47148/fbxw2