FCAMR (Fc fragment of IgA and IgM receptor)

2014-11-01  

Identity

HGNC
FCAMR
LOCATION
1q32.1
LOCUSID
83953
ALIAS
CD351,FCA/MR,FKSG87
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83953
MIM: 605484
HGNC: 24692
Ensembl: ENSG00000162897

Variants:

dbSNP: 83953
ClinVar: 83953
TCGA: ENSG00000162897
COSMIC: FCAMR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162897ENST00000324852A0A0B4J1S2
ENSG00000162897ENST00000324863F8W7R9
ENSG00000162897ENST00000400962Q8WWV6
ENSG00000162897ENST00000450945Q8WWV6

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
261380652015Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.35
183798682008Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque.12
196826892010Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages.8
200595782010Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17.6
258454912015Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis.6
283552322017A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.5
199451662010Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface.2
193387682009Human Fcalpha/muR and pIgR distribute differently in intestinal tissues.1
193936042009Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization.1

Citation

Dessen P

FCAMR (Fc fragment of IgA and IgM receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63345/fcamr