FCER1G (Fc fragment of IgE receptor Ig)

2008-07-01  

Identity

HGNC
FCER1G
LOCATION
1q23.3
LOCUSID
2207
ALIAS
FCRG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2207
MIM: 147139
HGNC: 3611
Ensembl: ENSG00000158869

Variants:

dbSNP: 2207
ClinVar: 2207
TCGA: ENSG00000158869
COSMIC: FCER1G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158869ENST00000289902P30273
ENSG00000158869ENST00000367992A6NCQ8

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Natural killer cell mediated cytotoxicityKEGGhsa04650
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Platelet activationKEGGhsa04611
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
HemostasisREACTOMER-HSA-109582
Platelet Adhesion to exposed collagenREACTOMER-HSA-75892
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD18534082, 18595682
PA448497aspirinChemicalClinicalAnnotationassociatedPD18534082, 18595682

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
178501792007BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells.63
157783392005Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein.50
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
227060862012CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.23
182925142008KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modules.21
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
292091412017Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma.19
201264042010The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells.15
232281552012Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia.15

Citation

Dessen P

FCER1G (Fc fragment of IgE receptor Ig)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50245/fcer1g