FCGR3A (Fc fragment of IgG receptor IIIa)

2007-09-01  

Identity

HGNC
FCGR3A
LOCATION
1q23.3
LOCUSID
2214
ALIAS
CD16,CD16A,FCG3,FCGR3,FCGRIII,FCR-10,FCRIII,FCRIIIA,IGFR3,IMD20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2214
MIM: 146740
HGNC: 3619
Ensembl: ENSG00000203747

Variants:

dbSNP: 2214
ClinVar: 2214
TCGA: ENSG00000203747
COSMIC: FCGR3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000203747ENST00000367967P08637
ENSG00000203747ENST00000367969M9MML0
ENSG00000203747ENST00000426740H0Y755
ENSG00000203747ENST00000436743P08637
ENSG00000203747ENST00000442336C9JC71
ENSG00000203747ENST00000443193P08637

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Systemic lupus erythematosusKEGGko05322
Natural killer cell mediated cytotoxicityKEGGhsa04650
Systemic lupus erythematosusKEGGhsa05322
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD24048425, 27044681
PA10040cetuximabChemicalClinicalAnnotationassociatedPD17704420, 23296156, 27897268, 28719596, 30318772
PA164743704antithymocyte globulinChemicalClinicalAnnotationassociated24322002
PA165292659tocilizumabChemicalClinicalAnnotationassociatedPD30457672
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociated24322002
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD19005160, 23505228, 25823782, 26167726, 30457672
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD18347005, 21109570
PA444841Lymphoma, FollicularDiseaseClinicalAnnotationassociatedPD12975461, 16609067, 19018870
PA444845Lymphoma, Non-HodgkinDiseaseClinicalAnnotationassociatedPD12975461, 16609067, 19018870
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD17704420, 23296156, 27897268, 28719596, 30318772
PA445109Neuromyelitis OpticaDiseaseClinicalAnnotationassociatedPD23505228, 26167726, 30457672
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD24048425, 27044681
PA446304Lymphoma, B-CellDiseaseClinicalAnnotationassociatedPD12975461, 16609067, 19018870
PA446313Lymphoma, Large-Cell, DiffuseDiseaseClinicalAnnotationassociatedPD12975461, 16609067, 19018870
PA449515etanerceptChemicalClinicalAnnotationassociatedPD24048425, 27044681
PA451261rituximabChemicalClinicalAnnotationassociatedPD12975461, 16609067, 19018870, 23505228, 26167726, 30457672
PA451743trastuzumabChemicalClinicalAnnotationassociatedPD18347005, 21109570
PA452639infliximabChemicalClinicalAnnotationassociatedPD19005160, 24048425, 25823782, 27044681

References

Pubmed IDYearTitleCitations
118069742002Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene.463
119863212002Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity.428
183470052008Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.303
183470052008Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.303
217683352011Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.218
174758892007The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.169
191642132009Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.153
191642132009Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.153
177044202007FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.138
177044202007FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.138

Citation

Dessen P

FCGR3A (Fc fragment of IgG receptor IIIa)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49750/fcgr3a