FCGR3B (Fc fragment of IgG receptor IIIb)

2007-02-01  

Identity

HGNC
FCGR3B
LOCATION
1q23.3
LOCUSID
2215
ALIAS
CD16,CD16A,CD16b,FCG3,FCGR3,FCGR3A,FCR-10,FCRIII,FCRIIIb

Other Information

Locus ID:

NCBI: 2215
MIM: 610665
HGNC: 3620
Ensembl: ENSG00000162747

Variants:

dbSNP: 2215
ClinVar: 2215
TCGA: ENSG00000162747
COSMIC: FCGR3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162747ENST00000367964O75015
ENSG00000162747ENST00000421702H0Y4U3
ENSG00000162747ENST00000534776E9PNY5
ENSG00000162747ENST00000613418A0A087WZR4
ENSG00000162747ENST00000614870A0A087WU90
ENSG00000162747ENST00000650385A0A3B3ISU3

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Systemic lupus erythematosusKEGGko05322
Natural killer cell mediated cytotoxicityKEGGhsa04650
Systemic lupus erythematosusKEGGhsa05322
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443434Arthritis, RheumatoidDiseaseMultilinkAnnotationassociated25966632

References

Pubmed IDYearTitleCitations
164821582006Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.261
175299782007FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.164
229997282012CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography.140
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
185594522008Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.82
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
193096902009Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.58
250243782014Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1.57
205080372010Copy number, linkage disequilibrium and disease association in the FCGR locus.51
205080372010Copy number, linkage disequilibrium and disease association in the FCGR locus.51

Citation

Dessen P

FCGR3B (Fc fragment of IgG receptor IIIb)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46575/fcgr3b