FCGRT (Fc fragment of IgG receptor and transporter)

2015-06-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
FCRN,alpha-chain
FUSION GENES

Other Information

Locus ID:

NCBI: 2217
MIM: 601437
HGNC: 3621
Ensembl: ENSG00000104870

Variants:

dbSNP: 2217
ClinVar: 2217
TCGA: ENSG00000104870
COSMIC: FCGRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104870ENST00000221466P55899
ENSG00000104870ENST00000221466A0A024QZI2
ENSG00000104870ENST00000426395P55899
ENSG00000104870ENST00000426395A0A024QZI2
ENSG00000104870ENST00000593381M0R220
ENSG00000104870ENST00000596975M0R0A9
ENSG00000104870ENST00000598076M0R0H0
ENSG00000104870ENST00000598319M0QYN1
ENSG00000104870ENST00000598491M0R266
ENSG00000104870ENST00000598927M0QYN9
ENSG00000104870ENST00000599701M0R2T3
ENSG00000104870ENST00000599988M0R0K7
ENSG00000104870ENST00000600273M0QYM4

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177032282007FcRn: the neonatal Fc receptor comes of age.567
117171962001Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies.144
147646662004Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.109
185994402008Dependence of antibody-mediated presentation of antigen on FcRn.99
200836592010Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.94
152582882004Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level.84
213681662011Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection.77
194512752009The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.68
173841512007Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy.65
156894942005From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.63

Citation

Dessen P

FCGRT (Fc fragment of IgG receptor and transporter)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55268/fcgrt