FCN3 (ficolin 3)

2013-11-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
FCNH,HAKA1
FUSION GENES

Other Information

Locus ID:

NCBI: 8547
MIM: 604973
HGNC: 3625
Ensembl: ENSG00000142748

Variants:

dbSNP: 8547
ClinVar: 8547
TCGA: ENSG00000142748
COSMIC: FCN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142748ENST00000270879O75636
ENSG00000142748ENST00000354982O75636
ENSG00000142748ENST00000354982Q6UXM4

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Lectin pathway of complement activationREACTOMER-HSA-166662
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceREACTOMER-HSA-2855086

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172158692007Structural insights into the innate immune recognition specificities of L- and H-ficolins.56
174691422007The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells.38
182617992008Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state.38
182617992008Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state.38
180060632008Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen).31
119071112002Activation of the lectin complement pathway by H-ficolin (Hakata antigen).27
191091772009Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
228517082012Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.27
199394952010MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation.19

Citation

Dessen P

FCN3 (ficolin 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53622/fcn3