FCRLA (Fc receptor like A)

2003-06-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
FCRL,FCRL1,FCRLM1,FCRLX,FCRLb,FCRLc1,FCRLc2,FCRLd,FCRLe,FCRX,FREB
FUSION GENES

Other Information

Locus ID:

NCBI: 84824
MIM: 606891
HGNC: 18504
Ensembl: ENSG00000132185

Variants:

dbSNP: 84824
ClinVar: 84824
TCGA: ENSG00000132185
COSMIC: FCRLA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132185ENST00000236938Q7L513
ENSG00000132185ENST00000294796Q7L513
ENSG00000132185ENST00000309691Q7L513
ENSG00000132185ENST00000349527Q7L513
ENSG00000132185ENST00000350710Q7L513
ENSG00000132185ENST00000367949Q7L513
ENSG00000132185ENST00000367950Q5VXA5
ENSG00000132185ENST00000367953Q7L513
ENSG00000132185ENST00000367957Q7L513
ENSG00000132185ENST00000367959Q7L513
ENSG00000132185ENST00000540521Q7L513
ENSG00000132185ENST00000546024Q7L513

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206682212010Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.18
211494182011FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA.14
270152732016FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells.6
155513502005Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.5
129665882003Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways.2
237427572013Characterization of human FCRLA isoforms.2
269805762016Response to Intravenous Cyclophosphamide Treatment for Lupus Nephritis Associated with Polymorphisms in the FCGR2B-FCRLA Locus.2
288795212017FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells.2
292363552018B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans.0

Citation

Dessen P

FCRLA (Fc receptor like A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40640/fcrla