Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FER (FER tyrosine kinase)

Identity

Alias_namesfer (fps/fes related) tyrosine kinase
Alias_symbol (synonym)TYK3
PPP1R74
Other aliasp94-Fer
HGNC (Hugo) FER
LocusID (NCBI) 2241
Atlas_Id 40544
Location 5q21.3  [Link to chromosome band 5q21]
Location_base_pair Starts at 108747822 and ends at 109196840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PJA2 (5q21.3) / FER (5q21.3)SSBP2 (5q14.1) / FER (5q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;5)(q14;q21) SSBP2/FER

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  MAN2A1/FER (5q21)
MAN2A1/FER (5q21)
MAN2A1/FER (5q21)
MAN2A1/FER (5q21)
MAN2A1/FER (5q21)
MAN2A1/FER (5q21)

External links

Nomenclature
HGNC (Hugo)FER   3655
Cards
Entrez_Gene (NCBI)FER  2241  FER tyrosine kinase
AliasesPPP1R74; TYK3; p94-Fer
GeneCards (Weizmann)FER
Ensembl hg19 (Hinxton)ENSG00000151422 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151422 [Gene_View]  ENSG00000151422 [Sequence]  chr5:108747822-109196840 [Contig_View]  FER [Vega]
ICGC DataPortalENSG00000151422
TCGA cBioPortalFER
AceView (NCBI)FER
Genatlas (Paris)FER
WikiGenes2241
SOURCE (Princeton)FER
Genetics Home Reference (NIH)FER
Genomic and cartography
GoldenPath hg38 (UCSC)FER  -     chr5:108747822-109196840 +  5q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FER  -     5q21.3   [Description]    (hg19-Feb_2009)
GoldenPathFER - 5q21.3 [CytoView hg19]  FER - 5q21.3 [CytoView hg38]
ImmunoBaseENSG00000151422
Mapping of homologs : NCBIFER [Mapview hg19]  FER [Mapview hg38]
OMIM176942   
Gene and transcription
Genbank (Entrez)AK021888 AK092320 AK123847 AK293376 AK296874
RefSeq transcript (Entrez)NM_001308028 NM_001308031 NM_001308038 NM_005246
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FER
Cluster EST : UnigeneHs.625304 [ NCBI ]
CGAP (NCI)Hs.625304
Alternative Splicing GalleryENSG00000151422
Gene ExpressionFER [ NCBI-GEO ]   FER [ EBI - ARRAY_EXPRESS ]   FER [ SEEK ]   FER [ MEM ]
Gene Expression Viewer (FireBrowse)FER [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2241
GTEX Portal (Tissue expression)FER
Human Protein AtlasENSG00000151422-FER [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16591   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16591  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16591
Splice isoforms : SwissVarP16591
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP16591
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    Fer    Fer_F-BAR    Fes/Fps/Fer_SH2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    Tyr-prot_kinase_Fes/Fps    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)FCH (PF00611)    Pkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
Conserved Domain (NCBI)FER
DMDM Disease mutations2241
Blocks (Seattle)FER
PDB (RSDB)2KK6   
PDB Europe2KK6   
PDB (PDBSum)2KK6   
PDB (IMB)2KK6   
Structural Biology KnowledgeBase2KK6   
SCOP (Structural Classification of Proteins)2KK6   
CATH (Classification of proteins structures)2KK6   
SuperfamilyP16591
Human Protein Atlas [tissue]ENSG00000151422-FER [tissue]
Peptide AtlasP16591
HPRD01491
IPIIPI00029263   IPI01010324   IPI00916874   IPI00965442   
Protein Interaction databases
DIP (DOE-UCLA)P16591
IntAct (EBI)P16591
FunCoupENSG00000151422
BioGRIDFER
STRING (EMBL)FER
ZODIACFER
Ontologies - Pathways
QuickGOP16591
Ontology : AmiGOmicrotubule cytoskeleton organization  mitotic cell cycle  nuclear chromatin  regulation of protein phosphorylation  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cell cortex  protein phosphorylation  chemotaxis  cell adhesion  tyrosine phosphorylation of STAT protein  protein phosphatase 1 binding  cell proliferation  positive regulation of cell proliferation  positive regulation of cell proliferation  lipid binding  regulation of lamellipodium assembly  regulation of fibroblast migration  actin cytoskeleton  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  lamellipodium  cell junction  positive regulation of cell migration  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  actin cytoskeleton reorganization  response to lipopolysaccharide  cellular response to insulin stimulus  negative regulation of mast cell activation involved in immune response  substrate adhesion-dependent cell spreading  cellular response to reactive oxygen species  extracellular matrix-cell signaling  intracellular signal transduction  cellular response to macrophage colony-stimulating factor stimulus  response to platelet-derived growth factor  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  Fc-epsilon receptor signaling pathway  Fc-epsilon receptor signaling pathway  Kit signaling pathway  regulation of epidermal growth factor receptor signaling pathway  regulation of cell proliferation  regulation of mast cell degranulation  cell-cell adhesion mediated by cadherin  protein autophosphorylation  platelet-derived growth factor receptor signaling pathway  platelet-derived growth factor receptor signaling pathway  diapedesis  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  
Ontology : EGO-EBImicrotubule cytoskeleton organization  mitotic cell cycle  nuclear chromatin  regulation of protein phosphorylation  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cell cortex  protein phosphorylation  chemotaxis  cell adhesion  tyrosine phosphorylation of STAT protein  protein phosphatase 1 binding  cell proliferation  positive regulation of cell proliferation  positive regulation of cell proliferation  lipid binding  regulation of lamellipodium assembly  regulation of fibroblast migration  actin cytoskeleton  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  lamellipodium  cell junction  positive regulation of cell migration  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  actin cytoskeleton reorganization  response to lipopolysaccharide  cellular response to insulin stimulus  negative regulation of mast cell activation involved in immune response  substrate adhesion-dependent cell spreading  cellular response to reactive oxygen species  extracellular matrix-cell signaling  intracellular signal transduction  cellular response to macrophage colony-stimulating factor stimulus  response to platelet-derived growth factor  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  Fc-epsilon receptor signaling pathway  Fc-epsilon receptor signaling pathway  Kit signaling pathway  regulation of epidermal growth factor receptor signaling pathway  regulation of cell proliferation  regulation of mast cell degranulation  cell-cell adhesion mediated by cadherin  protein autophosphorylation  platelet-derived growth factor receptor signaling pathway  platelet-derived growth factor receptor signaling pathway  diapedesis  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  
Pathways : KEGGAdherens junction   
NDEx NetworkFER
Atlas of Cancer Signalling NetworkFER
Wikipedia pathwaysFER
Orthology - Evolution
OrthoDB2241
GeneTree (enSembl)ENSG00000151422
Phylogenetic Trees/Animal Genes : TreeFamFER
HOGENOMP16591
Homologs : HomoloGeneFER
Homology/Alignments : Family Browser (UCSC)FER
Gene fusions - Rearrangements
Fusion : MitelmanSSBP2/FER [5q14.1/5q21.3]  [t(5;5)(q14;q21)]  
Fusion : QuiverFER
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFER [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FER
dbVarFER
ClinVarFER
1000_GenomesFER 
Exome Variant ServerFER
ExAC (Exome Aggregation Consortium)ENSG00000151422
GNOMAD BrowserENSG00000151422
Varsome BrowserFER
Genetic variants : HAPMAP2241
Genomic Variants (DGV)FER [DGVbeta]
DECIPHERFER [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFER 
Mutations
ICGC Data PortalFER 
TCGA Data PortalFER 
Broad Tumor PortalFER
OASIS PortalFER [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFER  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFER
Mutations and Diseases : HGMDFER
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FER
DgiDB (Drug Gene Interaction Database)FER
DoCM (Curated mutations)FER (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FER (select a term)
intoGenFER
Cancer3DFER(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176942   
Orphanet
DisGeNETFER
MedgenFER
Genetic Testing Registry FER
NextProtP16591 [Medical]
TSGene2241
GENETestsFER
Target ValidationFER
Huge Navigator FER [HugePedia]
snp3D : Map Gene to Disease2241
BioCentury BCIQFER
ClinGenFER
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2241
Chemical/Pharm GKB GenePA28095
Clinical trialFER
Miscellaneous
canSAR (ICR)FER (select the gene name)
DataMed IndexFER
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFER
EVEXFER
GoPubMedFER
iHOPFER
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:43:18 CET 2019
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