FFAR2 (free fatty acid receptor 2)

2011-02-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
FFA2R,GPR43

Other Information

Locus ID:

NCBI: 2867
MIM: 603823
HGNC: 4501
Ensembl: ENSG00000126262

Variants:

dbSNP: 2867
ClinVar: 2867
TCGA: ENSG00000126262
COSMIC: FFAR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126262ENST00000246549O15552
ENSG00000126262ENST00000246549C6KYL4
ENSG00000126262ENST00000599180O15552
ENSG00000126262ENST00000599180C6KYL4

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127116042003Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.333
126840412003Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.122
178994022008Expression of the short-chain fatty acid receptor, GPR43, in the human colon.75
209791062011G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer.62
255815192015Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.55
188017382008Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.37
230660162012Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.35
260231062015GPR43 Potentiates β-Cell Function in Obesity.35
260755762015An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.32
244581102014Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release.30

Citation

Dessen P

FFAR2 (free fatty acid receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52091/ffar2