FFAR3 (free fatty acid receptor 3)

2014-11-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
FFA3R,GPR41,GPR42

Other Information

Locus ID:

NCBI: 2865
MIM: 603821
HGNC: 4499
Ensembl: ENSG00000185897

Variants:

dbSNP: 2865
ClinVar: 2865
TCGA: ENSG00000185897
COSMIC: FFAR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185897ENST00000327809O14843
ENSG00000185897ENST00000327809A0A0K0PUW7
ENSG00000185897ENST00000594310O14843
ENSG00000185897ENST00000594310A0A0K0PUW7

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127116042003Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.333
147223612004Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.133
195747152009Expression of short-chain fatty acid receptor GPR41 in the human colon.73
243259072014Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.60
255815192015Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.55
188017382008Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.37
230660162012Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.35
212204282011Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.29
280753832017Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma.23
168873312007Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line.16

Citation

Dessen P

FFAR3 (free fatty acid receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63365/ffar3