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FGD6 (FYVE, RhoGEF and PH domain containing 6)

Identity

Alias_symbol (synonym)ZFYVE24
FLJ11183
Other alias
HGNC (Hugo) FGD6
LocusID (NCBI) 55785
Atlas_Id 63369
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 95076749 and ends at 95217464 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGD6 (12q22) / ARHGAP24 (4q21.23)FGD6 (12q22) / NUP37 (12q23.2)METTL25 (12q21.31) / FGD6 (12q22)
NDUFA12 (12q22) / FGD6 (12q22)SYT1 (12q21.2) / FGD6 (12q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGD6   21740
Cards
Entrez_Gene (NCBI)FGD6  55785  FYVE, RhoGEF and PH domain containing 6
AliasesZFYVE24
GeneCards (Weizmann)FGD6
Ensembl hg19 (Hinxton)ENSG00000180263 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180263 [Gene_View]  ENSG00000180263 [Sequence]  chr12:95076749-95217464 [Contig_View]  FGD6 [Vega]
ICGC DataPortalENSG00000180263
TCGA cBioPortalFGD6
AceView (NCBI)FGD6
Genatlas (Paris)FGD6
WikiGenes55785
SOURCE (Princeton)FGD6
Genetics Home Reference (NIH)FGD6
Genomic and cartography
GoldenPath hg38 (UCSC)FGD6  -     chr12:95076749-95217464 -  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGD6  -     12q22   [Description]    (hg19-Feb_2009)
GoldenPathFGD6 - 12q22 [CytoView hg19]  FGD6 - 12q22 [CytoView hg38]
ImmunoBaseENSG00000180263
Mapping of homologs : NCBIFGD6 [Mapview hg19]  FGD6 [Mapview hg38]
OMIM613520   
Gene and transcription
Genbank (Entrez)AB037783 AK002045 AK026881 AK124904 AK128492
RefSeq transcript (Entrez)NM_018351
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGD6
Cluster EST : UnigeneHs.506381 [ NCBI ]
CGAP (NCI)Hs.506381
Alternative Splicing GalleryENSG00000180263
Gene ExpressionFGD6 [ NCBI-GEO ]   FGD6 [ EBI - ARRAY_EXPRESS ]   FGD6 [ SEEK ]   FGD6 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55785
GTEX Portal (Tissue expression)FGD6
Human Protein AtlasENSG00000180263-FGD6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZV73   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZV73  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZV73
Splice isoforms : SwissVarQ6ZV73
PhosPhoSitePlusQ6ZV73
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    FGD6_N_PH    PH-like_dom_sf    PH_domain    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD6
DMDM Disease mutations55785
Blocks (Seattle)FGD6
SuperfamilyQ6ZV73
Human Protein Atlas [tissue]ENSG00000180263-FGD6 [tissue]
Peptide AtlasQ6ZV73
HPRD16892
IPIIPI00419100   IPI00471914   IPI00942099   IPI01022895   IPI01023038   IPI01022661   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZV73
IntAct (EBI)Q6ZV73
FunCoupENSG00000180263
BioGRIDFGD6
STRING (EMBL)FGD6
ZODIACFGD6
Ontologies - Pathways
QuickGOQ6ZV73
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of Rho protein signal transduction  regulation of GTPase activity  filopodium assembly  metal ion binding  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of Rho protein signal transduction  regulation of GTPase activity  filopodium assembly  metal ion binding  
NDEx NetworkFGD6
Atlas of Cancer Signalling NetworkFGD6
Wikipedia pathwaysFGD6
Orthology - Evolution
OrthoDB55785
GeneTree (enSembl)ENSG00000180263
Phylogenetic Trees/Animal Genes : TreeFamFGD6
HOGENOMQ6ZV73
Homologs : HomoloGeneFGD6
Homology/Alignments : Family Browser (UCSC)FGD6
Gene fusions - Rearrangements
Fusion : QuiverFGD6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD6
dbVarFGD6
ClinVarFGD6
1000_GenomesFGD6 
Exome Variant ServerFGD6
ExAC (Exome Aggregation Consortium)ENSG00000180263
GNOMAD BrowserENSG00000180263
Varsome BrowserFGD6
Genetic variants : HAPMAP55785
Genomic Variants (DGV)FGD6 [DGVbeta]
DECIPHERFGD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGD6 
Mutations
ICGC Data PortalFGD6 
TCGA Data PortalFGD6 
Broad Tumor PortalFGD6
OASIS PortalFGD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGD6
Mutations and Diseases : HGMDFGD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGD6
DgiDB (Drug Gene Interaction Database)FGD6
DoCM (Curated mutations)FGD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGD6 (select a term)
intoGenFGD6
Cancer3DFGD6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613520   
Orphanet
DisGeNETFGD6
MedgenFGD6
Genetic Testing Registry FGD6
NextProtQ6ZV73 [Medical]
TSGene55785
GENETestsFGD6
Target ValidationFGD6
Huge Navigator FGD6 [HugePedia]
snp3D : Map Gene to Disease55785
BioCentury BCIQFGD6
ClinGenFGD6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55785
Chemical/Pharm GKB GenePA134967436
Clinical trialFGD6
Miscellaneous
canSAR (ICR)FGD6 (select the gene name)
DataMed IndexFGD6
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGD6
EVEXFGD6
GoPubMedFGD6
iHOPFGD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:28:31 CEST 2019
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