Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGF7 (fibroblast growth factor 7)

Identity

Alias_namesfibroblast growth factor 7 (keratinocyte growth factor)
Alias_symbol (synonym)KGF
Other aliasHBGF-7
HGNC (Hugo) FGF7
LocusID (NCBI) 2252
Atlas_Id 40565
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 49423178 and ends at 49487326 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAB2 (11q14.1) / FGF7 (15q21.2)GAB2 11q14.1 / FGF7 15q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;15)(q14;q21) GAB2/FGF7

External links

Nomenclature
HGNC (Hugo)FGF7   3685
Cards
Entrez_Gene (NCBI)FGF7  2252  fibroblast growth factor 7
AliasesHBGF-7; KGF
GeneCards (Weizmann)FGF7
Ensembl hg19 (Hinxton)ENSG00000140285 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140285 [Gene_View]  ENSG00000140285 [Sequence]  chr15:49423178-49487326 [Contig_View]  FGF7 [Vega]
ICGC DataPortalENSG00000140285
TCGA cBioPortalFGF7
AceView (NCBI)FGF7
Genatlas (Paris)FGF7
WikiGenes2252
SOURCE (Princeton)FGF7
Genetics Home Reference (NIH)FGF7
Genomic and cartography
GoldenPath hg38 (UCSC)FGF7  -     chr15:49423178-49487326 +  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF7  -     15q21.2   [Description]    (hg19-Feb_2009)
GoldenPathFGF7 - 15q21.2 [CytoView hg19]  FGF7 - 15q21.2 [CytoView hg38]
ImmunoBaseENSG00000140285
Mapping of homologs : NCBIFGF7 [Mapview hg19]  FGF7 [Mapview hg38]
OMIM148180   
Gene and transcription
Genbank (Entrez)AK313160 BC010956 CR542002 DB206350 M60828
RefSeq transcript (Entrez)NM_002009
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF7
Cluster EST : UnigeneHs.567268 [ NCBI ]
CGAP (NCI)Hs.567268
Alternative Splicing GalleryENSG00000140285
Gene ExpressionFGF7 [ NCBI-GEO ]   FGF7 [ EBI - ARRAY_EXPRESS ]   FGF7 [ SEEK ]   FGF7 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2252
GTEX Portal (Tissue expression)FGF7
Human Protein AtlasENSG00000140285-FGF7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21781   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21781  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21781
Splice isoforms : SwissVarP21781
PhosPhoSitePlusP21781
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF7    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF7
DMDM Disease mutations2252
Blocks (Seattle)FGF7
SuperfamilyP21781
Human Protein Atlas [tissue]ENSG00000140285-FGF7 [tissue]
Peptide AtlasP21781
HPRD01022
IPIIPI00010403   IPI01019077   IPI00402119   
Protein Interaction databases
DIP (DOE-UCLA)P21781
IntAct (EBI)P21781
FunCoupENSG00000140285
BioGRIDFGF7
STRING (EMBL)FGF7
ZODIACFGF7
Ontologies - Pathways
QuickGOP21781
Ontology : AmiGOMAPK cascade  fibroblast growth factor receptor binding  protein binding  extracellular region  Golgi apparatus  signal transduction  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  epidermis development  response to wounding  mesenchymal cell proliferation  positive regulation of keratinocyte proliferation  hair follicle morphogenesis  actin cytoskeleton reorganization  protein localization to cell surface  chemoattractant activity  positive regulation of transcription, DNA-templated  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  positive regulation of keratinocyte migration  positive regulation of cell division  positive regulation of protein kinase B signaling  branching involved in salivary gland morphogenesis  positive regulation of epithelial cell proliferation involved in lung morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  secretion by lung epithelial cell involved in lung growth  
Ontology : EGO-EBIMAPK cascade  fibroblast growth factor receptor binding  protein binding  extracellular region  Golgi apparatus  signal transduction  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  epidermis development  response to wounding  mesenchymal cell proliferation  positive regulation of keratinocyte proliferation  hair follicle morphogenesis  actin cytoskeleton reorganization  protein localization to cell surface  chemoattractant activity  positive regulation of transcription, DNA-templated  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  positive regulation of keratinocyte migration  positive regulation of cell division  positive regulation of protein kinase B signaling  branching involved in salivary gland morphogenesis  positive regulation of epithelial cell proliferation involved in lung morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  secretion by lung epithelial cell involved in lung growth  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF7
Atlas of Cancer Signalling NetworkFGF7
Wikipedia pathwaysFGF7
Orthology - Evolution
OrthoDB2252
GeneTree (enSembl)ENSG00000140285
Phylogenetic Trees/Animal Genes : TreeFamFGF7
HOGENOMP21781
Homologs : HomoloGeneFGF7
Homology/Alignments : Family Browser (UCSC)FGF7
Gene fusions - Rearrangements
Fusion : MitelmanGAB2/FGF7 [11q14.1/15q21.2]  [t(11;15)(q14;q21)]  
Fusion PortalGAB2 11q14.1 FGF7 15q21.2 SKCM
Fusion : QuiverFGF7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF7
dbVarFGF7
ClinVarFGF7
1000_GenomesFGF7 
Exome Variant ServerFGF7
ExAC (Exome Aggregation Consortium)ENSG00000140285
GNOMAD BrowserENSG00000140285
Varsome BrowserFGF7
Genetic variants : HAPMAP2252
Genomic Variants (DGV)FGF7 [DGVbeta]
DECIPHERFGF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF7 
Mutations
ICGC Data PortalFGF7 
TCGA Data PortalFGF7 
Broad Tumor PortalFGF7
OASIS PortalFGF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGF7
Mutations and Diseases : HGMDFGF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF7
DgiDB (Drug Gene Interaction Database)FGF7
DoCM (Curated mutations)FGF7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF7 (select a term)
intoGenFGF7
Cancer3DFGF7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148180   
Orphanet
DisGeNETFGF7
MedgenFGF7
Genetic Testing Registry FGF7
NextProtP21781 [Medical]
TSGene2252
GENETestsFGF7
Target ValidationFGF7
Huge Navigator FGF7 [HugePedia]
snp3D : Map Gene to Disease2252
BioCentury BCIQFGF7
ClinGenFGF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2252
Chemical/Pharm GKB GenePA28124
Clinical trialFGF7
Miscellaneous
canSAR (ICR)FGF7 (select the gene name)
DataMed IndexFGF7
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF7
EVEXFGF7
GoPubMedFGF7
iHOPFGF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:43:26 CET 2019
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