FGFRL1 (fibroblast growth factor receptor like 1)

2007-02-01 Affiliation

Identity

HGNC

FGFRL1

LOCATION

4p16.3

LOCUSID

53834

ALIAS

FGFR-5,FGFR5,FHFR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 53834
MIM: 605830
HGNC: 3693
Ensembl: ENSG00000127418

Variants:

dbSNP: 53834
ClinVar: 53834
TCGA: ENSG00000127418
COSMIC: FGFRL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000127418	ENST00000264748	Q8N441
ENSG00000127418	ENST00000398484	Q8N441
ENSG00000127418	ENST00000504138	Q8N441
ENSG00000127418	ENST00000507339	D6RBN8
ENSG00000127418	ENST00000510644	Q8N441
ENSG00000127418	ENST00000512174	D6REM7

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
FGFRL1 modulation of FGFR1 signaling	REACTOME	R-HSA-5658623

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA164924492	brivanib	Chemical	Pathway	associated	20124951
PA26880	CRK	Gene	Pathway	associated	20124951
PA28115	FGF2	Gene	Pathway	associated	20124951
PA33304	PIK3C2A	Gene	Pathway	associated	20124951
PA33305	PIK3C2B	Gene	Pathway	associated	20124951

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
21044961	2011	MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).	80
16019430	2005	Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells.	27
19920134	2010	The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos.	24
20453000	2010	A Large-scale genetic association study of esophageal adenocarcinoma risk.	23
19056490	2009	Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient.	18
27666683	2016	MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma.	15
18061161	2008	The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion.	14
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
20184660	2010	Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells.	10

Citation

Dessen P

FGFRL1 (fibroblast growth factor receptor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43781/fgfrl1