FKBP1A (FKBP prolyl isomerase 1A)

2008-07-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
FKBP-12,FKBP-1A,FKBP1,FKBP12,PKC12,PKCI2,PPIASE
FUSION GENES

Other Information

Locus ID:

NCBI: 2280
MIM: 186945
HGNC: 3711
Ensembl: ENSG00000088832

Variants:

dbSNP: 2280
ClinVar: 2280
TCGA: ENSG00000088832
COSMIC: FKBP1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088832ENST00000381715Q5W0X3
ENSG00000088832ENST00000381719P62942
ENSG00000088832ENST00000381724Q5W0X3
ENSG00000088832ENST00000400137P62942
ENSG00000088832ENST00000439640Q1JUQ5
ENSG00000088832ENST00000612074Q1JUQ3
ENSG00000088832ENST00000614856A0A087WZM5
ENSG00000088832ENST00000618612A0A087WTS4

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by TGF-beta Receptor Complex in CancerREACTOMER-HSA-3304351
Loss of Function of TGFBR2 in CancerREACTOMER-HSA-3642278
TGFBR2 Kinase Domain Mutants in CancerREACTOMER-HSA-3645790
Loss of Function of TGFBR1 in CancerREACTOMER-HSA-3656534
TGFBR1 LBD Mutants in CancerREACTOMER-HSA-3656535
TGFBR1 KD Mutants in CancerREACTOMER-HSA-3656532
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385706262024The high FKBP1A expression in WBCs as a potential screening biomarker for pancreatic cancer.0
387258432024HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis.0
385706262024The high FKBP1A expression in WBCs as a potential screening biomarker for pancreatic cancer.0
387258432024HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis.0
376258382023Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression.0
376258382023Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression.0
348829002022FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.6
363615872022The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma.3
364992752022Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway.4
348829002022FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.6
363615872022The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma.3
364992752022Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway.4
344690092021CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.3
345991462021FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma.4
344690092021CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.3

Citation

Dessen P

FKBP1A (FKBP prolyl isomerase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50277/fkbp1a