FLII (FLII actin remodeling protein)

2017-01-01  

Identity

HGNC
FLII
LOCATION
17p11.2
LOCUSID
2314
ALIAS
FLI,FLIL,Fli1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2314
MIM: 600362
HGNC: 3750
Ensembl: ENSG00000177731

Variants:

dbSNP: 2314
ClinVar: 2314
TCGA: ENSG00000177731
COSMIC: FLII

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177731ENST00000327031Q13045
ENSG00000177731ENST00000473425K7EP37
ENSG00000177731ENST00000488932J3QQQ2
ENSG00000177731ENST00000545457Q13045
ENSG00000177731ENST00000577398K7EQZ7
ENSG00000177731ENST00000577485J3QLR6
ENSG00000177731ENST00000577626J3QQU5
ENSG00000177731ENST00000578101J3KS39
ENSG00000177731ENST00000578558J3KS54
ENSG00000177731ENST00000579294Q13045
ENSG00000177731ENST00000581349K7EP27
ENSG00000177731ENST00000581401J3KT47
ENSG00000177731ENST00000581858K7EJJ7
ENSG00000177731ENST00000628188J3KS39

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
149662892004Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.48
192651232009Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.26
119719822002Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.23
197208352009Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.21
202238272010Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.21
175264232008Flightless I: an actin-remodelling protein and an important negative regulator of wound repair.17
192931512009Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
185888812008Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II.10

Citation

Dessen P

FLII (FLII actin remodeling protein)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56692/flii