FLOT1 (flotillin 1)

2009-08-01  

Identity

HGNC
FLOT1
LOCATION
6p21.33
LOCUSID
10211
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10211
MIM: 606998
HGNC: 3757
Ensembl: ENSG00000137312

Variants:

dbSNP: 10211
ClinVar: 10211
TCGA: ENSG00000137312
COSMIC: FLOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137312ENST00000376389O75955
ENSG00000137312ENST00000376389Q5ST80
ENSG00000137312ENST00000413165A2AB09
ENSG00000137312ENST00000416018A2AB11
ENSG00000137312ENST00000418160A2ABJ5
ENSG00000137312ENST00000438162A2AB10
ENSG00000137312ENST00000445853A2AB12
ENSG00000137312ENST00000454845A2AB13

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163412062006Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells.187
213996312011Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT.84
176007092007Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.83
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
192583922009Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.48
193181232009Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.46
211874332011Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.46
214477262011Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a.43
243307802013Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer.43
175873292007Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection.42

Citation

Dessen P

FLOT1 (flotillin 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51013/flot1