FLRT3 (fibronectin leucine rich transmembrane protein 3)

2014-11-01  

Identity

HGNC
FLRT3
LOCATION
20p12.1
LOCUSID
23767
ALIAS
HH21

Other Information

Locus ID:

NCBI: 23767
MIM: 604808
HGNC: 3762
Ensembl: ENSG00000125848

Variants:

dbSNP: 23767
ClinVar: 23767
TCGA: ENSG00000125848
COSMIC: FLRT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125848ENST00000341420Q9NZU0
ENSG00000125848ENST00000378053Q9NZU0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR1REACTOMER-HSA-5654736
Downstream signaling of activated FGFR1REACTOMER-HSA-5654687

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224052012012FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.77
262350302015Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.33
274219692017Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion.3
185938712008Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki syndrome in Japan.2

Citation

Dessen P

FLRT3 (fibronectin leucine rich transmembrane protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63541/flrt3