FLT1 (fms related receptor tyrosine kinase 1)

2003-02-01  

Identity

HGNC
FLT1
LOCATION
13q12.3
LOCUSID
2321
ALIAS
FLT,FLT-1,VEGFR-1,VEGFR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2321
MIM: 165070
HGNC: 3763
Ensembl: ENSG00000102755

Variants:

dbSNP: 2321
ClinVar: 2321
TCGA: ENSG00000102755
COSMIC: FLT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102755ENST00000282397P17948
ENSG00000102755ENST00000282397L7RSL3
ENSG00000102755ENST00000539099P17948
ENSG00000102755ENST00000540678H9N1E8
ENSG00000102755ENST00000541932P17948
ENSG00000102755ENST00000543394P17948
ENSG00000102755ENST00000615611H9N1E7
ENSG00000102755ENST00000615840P17948
ENSG00000102755ENST00000617835H9N1E8
ENSG00000102755ENST00000639477A0A1W2PNW4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
Neurophilin interactions with VEGF and VEGFRREACTOMER-HSA-194306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalMultilinkAnnotation, Pathway, VariantAnnotationassociatedPD19248971, 20124951, 26935927
PA164924493axitinibChemicalPathwayassociated20124951
PA166118340motesanibChemicalPathwayassociated20124951
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD26935927
PA29444HRASGenePathwayassociated28362716
PA30196KRASGenePathwayassociated28362716
PA31768NRASGenePathwayassociated28362716
PA33304PIK3C2AGenePathwayassociated28362716
PA33305PIK3C2BGenePathwayassociated28362716
PA33308PIK3CAGenePathwayassociated28362716
PA33309PIK3CBGenePathwayassociated28362716
PA33310PIK3CDGenePathwayassociated28362716
PA33311PIK3CGGenePathwayassociated28362716
PA33312PIK3R1GenePathwayassociated28362716
PA33313PIK3R2GenePathwayassociated28362716
PA33314PIK3R3GenePathwayassociated28362716
PA37302VEGFAGenePathwayassociated20124951
PA37303VEGFBGenePathwayassociated20124951
PA37304VEGFCGenePathwayassociated20124951
PA443624Carcinoma, Renal CellDiseaseVariantAnnotationassociatedPD26935927
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
376953582024A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.3
378896022024Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.0
381418892024SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.0
382418392024Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.0
382957202024Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.0
383245852024Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.3
383967192024Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.0
376953582024A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.3
378896022024Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.0
381418892024SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.0
382418392024Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.0
382957202024Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.0
383245852024Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.3
383967192024Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.0
369223272023Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.1

Citation

Dessen P

FLT1 (fms related receptor tyrosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40610/flt1