Identity
HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,PCL,VEGFR-3,VEGFR3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2324
MIM: 136352
HGNC: 3767
Ensembl: ENSG00000037280
Variants:
dbSNP: 2324
ClinVar: 2324
TCGA: ENSG00000037280
COSMIC: FLT4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162372840 | sunitinib | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 19248971, 22015057 | |
| PA29444 | HRAS | Gene | Pathway | associated | 28362716 | ||
| PA30196 | KRAS | Gene | Pathway | associated | 28362716 | ||
| PA31768 | NRAS | Gene | Pathway | associated | 28362716 | ||
| PA33304 | PIK3C2A | Gene | Pathway | associated | 28362716 | ||
| PA33305 | PIK3C2B | Gene | Pathway | associated | 28362716 | ||
| PA33308 | PIK3CA | Gene | Pathway | associated | 28362716 | ||
| PA33309 | PIK3CB | Gene | Pathway | associated | 28362716 | ||
| PA33310 | PIK3CD | Gene | Pathway | associated | 28362716 | ||
| PA33311 | PIK3CG | Gene | Pathway | associated | 28362716 | ||
| PA33312 | PIK3R1 | Gene | Pathway | associated | 28362716 | ||
| PA33313 | PIK3R2 | Gene | Pathway | associated | 28362716 | ||
| PA33314 | PIK3R3 | Gene | Pathway | associated | 28362716 | ||
| PA443624 | Carcinoma, Renal Cell | Disease | ClinicalAnnotation | associated | PD | 22015057 | |
| PA7000 | sorafenib | Chemical | Pathway | associated | 28362716 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38269589 | 2024 | Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis. | 1 |
| 38518198 | 2024 | The pathological roles and potential mechanisms of vascular endothelial growth factor receptor-3 in gastric cancer. | 0 |
| 38581027 | 2024 | Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China. | 1 |
| 38728943 | 2024 | miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3. | 0 |
| 38269589 | 2024 | Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis. | 1 |
| 38518198 | 2024 | The pathological roles and potential mechanisms of vascular endothelial growth factor receptor-3 in gastric cancer. | 0 |
| 38581027 | 2024 | Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China. | 1 |
| 38728943 | 2024 | miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3. | 0 |
| 36538874 | 2023 | Two novel variations p.(Ser1275Thr) and p.(Ser1275Arg) in FLT4 causing prenatal hereditary lymphedema type 1. | 0 |
| 36835014 | 2023 | High VEGFR3 Expression Reduces Doxorubicin Efficacy in Triple-Negative Breast Cancer. | 1 |
| 36922713 | 2023 | VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways. | 1 |
| 37317880 | 2023 | FLT4 as a marker for predicting prognostic risk of refractory acute myeloid leukemia. | 0 |
| 37454290 | 2023 | VEGFR3 is required for button junction formation in lymphatic vessels. | 5 |
| 36538874 | 2023 | Two novel variations p.(Ser1275Thr) and p.(Ser1275Arg) in FLT4 causing prenatal hereditary lymphedema type 1. | 0 |
| 36835014 | 2023 | High VEGFR3 Expression Reduces Doxorubicin Efficacy in Triple-Negative Breast Cancer. | 1 |
Citation
Dessen P
FLT4 (fms related receptor tyrosine kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40612/flt4
