FMNL2 (formin like 2)

2008-12-01  

Identity

HGNC
FMNL2
LOCATION
2q23.3
LOCUSID
114793
ALIAS
FHOD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114793
MIM: 616285
HGNC: 18267
Ensembl: ENSG00000157827

Variants:

dbSNP: 114793
ClinVar: 114793
TCGA: ENSG00000157827
COSMIC: FMNL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157827ENST00000288670Q96PY5
ENSG00000157827ENST00000475377C9IZY8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
226085132012FMNL2 drives actin-based protrusion and migration downstream of Cdc42.74
232011622013MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201012122010Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.60
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
186653742008Overexpression of FMNL2 is closely related to metastasis of colorectal cancer.31
210715122010FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition.30
265647752015Formin and capping protein together embrace the actin filament in a ménage à trois.26
265156962016MicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2.25
259638182015Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1.22

Citation

Dessen P

FMNL2 (formin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50600/fmnl2