FMO1 (flavin containing dimethylaniline monoxygenase 1)

2003-08-01 Affiliation

Identity

HGNC

FMO1

LOCATION

1q24.3

LOCUSID

2326

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2326
MIM: 136130
HGNC: 3769
Ensembl: ENSG00000010932

Variants:

dbSNP: 2326
ClinVar: 2326
TCGA: ENSG00000010932
COSMIC: FMO1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000010932	ENST00000354841	Q01740
ENSG00000010932	ENST00000354841	A0A024R934
ENSG00000010932	ENST00000367750	Q01740
ENSG00000010932	ENST00000367750	A0A024R934
ENSG00000010932	ENST00000402921	Q01740
ENSG00000010932	ENST00000469112	A0A1W2PNR8
ENSG00000010932	ENST00000617670	Q01740
ENSG00000010932	ENST00000617670	A0A024R934

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
FMO oxidises nucleophiles	REACTOME	R-HSA-217271

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PMIDs
PA450626	nicotine	Chemical	ClinicalAnnotation	associated
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PK	23147717
PA451581	tamoxifen	Chemical	Pathway	associated		23962908

References

Pubmed ID	Year	Title	Citations
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
11809920	2002	Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression.	41
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
16183778	2006	Quantitative analysis of FMO gene mRNA levels in human tissues.	30
29080679	2018	SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin.	26
19336370	2009	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	17
16863467	2006	Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3.	16
20056567	2010	Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.	14
15203093	2004	The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development.	11
20529763	2010	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	8

Citation

Dessen P

FMO1 (flavin containing dimethylaniline monoxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40614/fmo1