FMO5 (flavin containing dimethylaniline monoxygenase 5)

2003-08-01  

Identity

HGNC
FMO5
LOCATION
1q21.1
LOCUSID
2330
ALIAS
hBVMO1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2330
MIM: 603957
HGNC: 3773
Ensembl: ENSG00000131781

Variants:

dbSNP: 2330
ClinVar: 2330
TCGA: ENSG00000131781
COSMIC: FMO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131781ENST00000254090P49326
ENSG00000131781ENST00000254090A0A024QYY6
ENSG00000131781ENST00000369272P49326
ENSG00000131781ENST00000441068P49326
ENSG00000131781ENST00000527849E9PJF3
ENSG00000131781ENST00000533174E9PP51
ENSG00000131781ENST00000533848E9PQ84
ENSG00000131781ENST00000578284P49326

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - cytochrome P450KEGGhsa00982

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD26306225
PA450395metforminChemicalClinicalAnnotationassociatedPD26306225

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
161837782006Quantitative analysis of FMO gene mRNA levels in human tissues.30
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
267716712016Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans.7
268393692016Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny.5
287833002017Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.3

Citation

Dessen P

FMO5 (flavin containing dimethylaniline monoxygenase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40615/fmo5