FNBP1L (formin binding protein 1 like)

2013-09-01  

Identity

HGNC
FNBP1L
LOCATION
1p22.1
LOCUSID
54874
ALIAS
C1orf39,TOCA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54874
MIM: 608848
HGNC: 20851
Ensembl: ENSG00000137942

Variants:

dbSNP: 54874
ClinVar: 54874
TCGA: ENSG00000137942
COSMIC: FNBP1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137942ENST00000260506Q5T0N5
ENSG00000137942ENST00000271234Q5T0N5
ENSG00000137942ENST00000370253Q5T0N5
ENSG00000137942ENST00000424449A0A075B6Q2
ENSG00000137942ENST00000604705S4R347

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152609902004Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.155
233581562014Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192137342009The Toca-1-N-WASP complex links filopodial formation to endocytosis.37
193426712009A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.30
193426712009A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.30
207301032010Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis.30
168851582006Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination.27
181917932008Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition.27
210627392011Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness.18

Citation

Dessen P

FNBP1L (formin binding protein 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53509/fnbp1l