Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FOLH1 (folate hydrolase 1)

Identity

Alias_namesFOLH
folate hydrolase (prostate-specific membrane antigen) 1
Alias_symbol (synonym)PSM
PSMA
NAALAD1
NAALAdase
GCP2
GCPII
Other aliasFGCP
mGCP
HGNC (Hugo) FOLH1
LocusID (NCBI) 2346
Atlas_Id 40619
Location 11p11.12  [Link to chromosome band 11p11]
Location_base_pair Starts at 49145094 and ends at 49208670 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOLH1   3788
Cards
Entrez_Gene (NCBI)FOLH1  2346  folate hydrolase 1
AliasesFGCP; FOLH; GCP2; GCPII; 
NAALAD1; NAALAdase; PSM; PSMA; mGCP
GeneCards (Weizmann)FOLH1
Ensembl hg19 (Hinxton)ENSG00000086205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086205 [Gene_View]  ENSG00000086205 [Sequence]  chr11:49145094-49208670 [Contig_View]  FOLH1 [Vega]
ICGC DataPortalENSG00000086205
TCGA cBioPortalFOLH1
AceView (NCBI)FOLH1
Genatlas (Paris)FOLH1
WikiGenes2346
SOURCE (Princeton)FOLH1
Genetics Home Reference (NIH)FOLH1
Genomic and cartography
GoldenPath hg38 (UCSC)FOLH1  -     chr11:49145094-49208670 -  11p11.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOLH1  -     11p11.12   [Description]    (hg19-Feb_2009)
GoldenPathFOLH1 - 11p11.12 [CytoView hg19]  FOLH1 - 11p11.12 [CytoView hg38]
ImmunoBaseENSG00000086205
Mapping of homologs : NCBIFOLH1 [Mapview hg19]  FOLH1 [Mapview hg38]
OMIM600934   
Gene and transcription
Genbank (Entrez)AF027824 AF176574 AF254357 AF254358 AJ007318
RefSeq transcript (Entrez)NM_001014986 NM_001193471 NM_001193472 NM_001193473 NM_001351236 NM_004476
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOLH1
Cluster EST : UnigeneHs.654487 [ NCBI ]
CGAP (NCI)Hs.654487
Alternative Splicing GalleryENSG00000086205
Gene ExpressionFOLH1 [ NCBI-GEO ]   FOLH1 [ EBI - ARRAY_EXPRESS ]   FOLH1 [ SEEK ]   FOLH1 [ MEM ]
Gene Expression Viewer (FireBrowse)FOLH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2346
GTEX Portal (Tissue expression)FOLH1
Human Protein AtlasENSG00000086205-FOLH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04609   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04609  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04609
Splice isoforms : SwissVarQ04609
Catalytic activity : Enzyme3.4.17.21 [ Enzyme-Expasy ]   3.4.17.213.4.17.21 [ IntEnz-EBI ]   3.4.17.21 [ BRENDA ]   3.4.17.21 [ KEGG ]   
PhosPhoSitePlusQ04609
Domains : Interpro (EBI)PA_domain    Peptidase_M28    TFR-like_dimer_dom    TFR-like_dimer_dom_sf   
Domain families : Pfam (Sanger)PA (PF02225)    Peptidase_M28 (PF04389)    TFR_dimer (PF04253)   
Domain families : Pfam (NCBI)pfam02225    pfam04389    pfam04253   
Conserved Domain (NCBI)FOLH1
DMDM Disease mutations2346
Blocks (Seattle)FOLH1
PDB (RSDB)1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
PDB Europe1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
PDB (PDBSum)1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
PDB (IMB)1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
Structural Biology KnowledgeBase1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
SCOP (Structural Classification of Proteins)1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
CATH (Classification of proteins structures)1Z8L    2C6C    2C6G    2C6P    2CIJ    2JBJ    2JBK    2OOT    2OR4    2PVV    2PVW    2XEF    2XEG    2XEI    2XEJ    3BHX    3BI0    3BI1    3BXM    3D7D    3D7F    3D7G    3D7H    3IWW    3RBU    3SJE    3SJF    3SJG    3SJX    4JYW    4JZ0    4LQG    4MCP    4MCQ    4MCR    4MCS    4NGM    4NGN    4NGP    4NGQ    4NGR    4NGS    4NGT    4OC0    4OC1    4OC2    4OC3    4OC4    4OC5    4OME    4P44    4P45    4P4B    4P4D    4P4E    4P4F    4P4I    4P4J    4W9Y    4X3R    5D29    5ELY    5F09   
SuperfamilyQ04609
Human Protein Atlas [tissue]ENSG00000086205-FOLH1 [tissue]
Peptide AtlasQ04609
HPRD02961
IPIIPI00028514   IPI01012792   IPI00216908   IPI00216910   IPI00944663   IPI00944595   IPI00973065   IPI00216907   IPI00956242   IPI01009620   IPI00979907   IPI00985121   IPI00982246   
Protein Interaction databases
DIP (DOE-UCLA)Q04609
IntAct (EBI)Q04609
FunCoupENSG00000086205
BioGRIDFOLH1
STRING (EMBL)FOLH1
ZODIACFOLH1
Ontologies - Pathways
QuickGOQ04609
Ontology : AmiGOcarboxypeptidase activity  metallocarboxypeptidase activity  cytoplasm  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  folic acid-containing compound metabolic process  peptidase activity  cellular amino acid biosynthetic process  cell surface  membrane  dipeptidase activity  C-terminal protein deglutamylation  metal ion binding  extracellular exosome  Ac-Asp-Glu binding  tetrahydrofolyl-poly(glutamate) polymer binding  
Ontology : EGO-EBIcarboxypeptidase activity  metallocarboxypeptidase activity  cytoplasm  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  proteolysis  folic acid-containing compound metabolic process  peptidase activity  cellular amino acid biosynthetic process  cell surface  membrane  dipeptidase activity  C-terminal protein deglutamylation  metal ion binding  extracellular exosome  Ac-Asp-Glu binding  tetrahydrofolyl-poly(glutamate) polymer binding  
Pathways : KEGGVitamin digestion and absorption   
NDEx NetworkFOLH1
Atlas of Cancer Signalling NetworkFOLH1
Wikipedia pathwaysFOLH1
Orthology - Evolution
OrthoDB2346
GeneTree (enSembl)ENSG00000086205
Phylogenetic Trees/Animal Genes : TreeFamFOLH1
HOGENOMQ04609
Homologs : HomoloGeneFOLH1
Homology/Alignments : Family Browser (UCSC)FOLH1
Gene fusions - Rearrangements
Fusion : QuiverFOLH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOLH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOLH1
dbVarFOLH1
ClinVarFOLH1
1000_GenomesFOLH1 
Exome Variant ServerFOLH1
ExAC (Exome Aggregation Consortium)ENSG00000086205
GNOMAD BrowserENSG00000086205
Varsome BrowserFOLH1
Genetic variants : HAPMAP2346
Genomic Variants (DGV)FOLH1 [DGVbeta]
DECIPHERFOLH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOLH1 
Mutations
ICGC Data PortalFOLH1 
TCGA Data PortalFOLH1 
Broad Tumor PortalFOLH1
OASIS PortalFOLH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOLH1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOLH1
Mutations and Diseases : HGMDFOLH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOLH1
DgiDB (Drug Gene Interaction Database)FOLH1
DoCM (Curated mutations)FOLH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOLH1 (select a term)
intoGenFOLH1
Cancer3DFOLH1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600934   
Orphanet
DisGeNETFOLH1
MedgenFOLH1
Genetic Testing Registry FOLH1
NextProtQ04609 [Medical]
TSGene2346
GENETestsFOLH1
Target ValidationFOLH1
Huge Navigator FOLH1 [HugePedia]
snp3D : Map Gene to Disease2346
BioCentury BCIQFOLH1
ClinGenFOLH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2346
Chemical/Pharm GKB GenePA28205
Clinical trialFOLH1
Miscellaneous
canSAR (ICR)FOLH1 (select the gene name)
DataMed IndexFOLH1
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOLH1
EVEXFOLH1
GoPubMedFOLH1
iHOPFOLH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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