| Nomenclature |
|---|
| HGNC (Hugo) | FOXA2 5022 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FOXA2 3170 forkhead box A2 |
| Aliases | HNF3B; TCF3B |
| GeneCards (Weizmann) | FOXA2 |
| Ensembl hg19 (Hinxton) | ENSG00000125798 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000125798 [Gene_View] ENSG00000125798 [Sequence] chr20:22581004-22585463 [Contig_View] FOXA2 [Vega] |
| ICGC DataPortal | ENSG00000125798 |
| TCGA cBioPortal | FOXA2 |
| AceView (NCBI) | FOXA2 |
| Genatlas (Paris) | FOXA2 |
| WikiGenes | 3170 |
| SOURCE (Princeton) | FOXA2 |
| Genetics Home Reference (NIH) | FOXA2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOXA2 - chr20:22581004-22585463 - 20p11.21 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOXA2 - 20p11.21 [Description] (hg19-Feb_2009) |
| GoldenPath | FOXA2 - 20p11.21 [CytoView hg19] FOXA2 - 20p11.21 [CytoView hg38] |
| ImmunoBase | ENSG00000125798 |
| Mapping of homologs : NCBI | FOXA2 [Mapview hg19] FOXA2 [Mapview hg38] |
| OMIM | 600288 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA469087 AB028021 AI268650 AI302734 AK301611 |
| RefSeq transcript (Entrez) | NM_021784 NM_153675 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOXA2 |
| Cluster EST : Unigene | Hs.155651 [ NCBI ] |
| CGAP (NCI) | Hs.155651 |
| Alternative Splicing Gallery | ENSG00000125798 |
| Gene Expression | FOXA2 [ NCBI-GEO ] FOXA2 [ EBI - ARRAY_EXPRESS ]
FOXA2 [ SEEK ] FOXA2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXA2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3170 |
| GTEX Portal (Tissue expression) | FOXA2 |
| Human Protein Atlas | ENSG00000125798-FOXA2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9Y261 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9Y261 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9Y261 |
| Splice isoforms : SwissVar | Q9Y261 |
| PhosPhoSitePlus | Q9Y261 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_1 (PS00657) FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) |
| Domains : Interpro (EBI) | Fork-head_N Fork_head_dom Forkhead_box_C TF_fork_head_CS_1 TF_fork_head_CS_2 WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) Forkhead_N (PF08430) HNF_C (PF09354) |
| Domain families : Pfam (NCBI) | pfam00250 pfam08430 pfam09354 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| Conserved Domain (NCBI) | FOXA2 |
| DMDM Disease mutations | 3170 |
| Blocks (Seattle) | FOXA2 |
| PDB (RSDB) | 5X07 |
| PDB Europe | 5X07 |
| PDB (PDBSum) | 5X07 |
| PDB (IMB) | 5X07 |
| Structural Biology KnowledgeBase | 5X07 |
| SCOP (Structural Classification of Proteins) | 5X07 |
| CATH (Classification of proteins structures) | 5X07 |
| Superfamily | Q9Y261 |
| Human Protein Atlas [tissue] | ENSG00000125798-FOXA2 [tissue] |
| Peptide Atlas | Q9Y261 |
| HPRD | 02618 |
| IPI | IPI00031773 IPI00908346 IPI00910912 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9Y261 |
| IntAct (EBI) | Q9Y261 |
| FunCoup | ENSG00000125798 |
| BioGRID | FOXA2 |
| STRING (EMBL) | FOXA2 |
| ZODIAC | FOXA2 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9Y261 |
| Ontology : AmiGO | positive regulation of transcription from RNA polymerase II promoter by glucose RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cell fate specification DNA binding DNA-binding transcription factor activity nucleus nucleus nucleoplasm cytoplasm chromatin organization regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription factor binding adult locomotory behavior anatomical structure morphogenesis negative regulation of epithelial to mesenchymal transition protein domain specific binding cell junction cell differentiation regulation of blood coagulation endocrine pancreas development negative regulation of glucokinase activity positive regulation of embryonic development negative regulation of DNA-binding transcription factor activity transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of transcription from RNA polymerase II promoter by glucose response to interleukin-6 dopaminergic neuron differentiation dopaminergic neuron differentiation dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation negative regulation of detection of glucose |
| Ontology : EGO-EBI | positive regulation of transcription from RNA polymerase II promoter by glucose RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cell fate specification DNA binding DNA-binding transcription factor activity nucleus nucleus nucleoplasm cytoplasm chromatin organization regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription factor binding adult locomotory behavior anatomical structure morphogenesis negative regulation of epithelial to mesenchymal transition protein domain specific binding cell junction cell differentiation regulation of blood coagulation endocrine pancreas development negative regulation of glucokinase activity positive regulation of embryonic development negative regulation of DNA-binding transcription factor activity transcription regulatory region DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of transcription from RNA polymerase II promoter by glucose response to interleukin-6 dopaminergic neuron differentiation dopaminergic neuron differentiation dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation negative regulation of detection of glucose |
| Pathways : KEGG | Maturity onset diabetes of the young |
| NDEx Network | FOXA2 |
| Atlas of Cancer Signalling Network | FOXA2 |
| Wikipedia pathways | FOXA2 |
| Orthology - Evolution |
|---|
| OrthoDB | 3170 |
| GeneTree (enSembl) | ENSG00000125798 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXA2 |
| HOGENOM | Q9Y261 |
| Homologs : HomoloGene | FOXA2 |
| Homology/Alignments : Family Browser (UCSC) | FOXA2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | FOXA2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOXA2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXA2 |
| dbVar | FOXA2 |
| ClinVar | FOXA2 |
| 1000_Genomes | FOXA2 |
| Exome Variant Server | FOXA2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000125798 |
| GNOMAD Browser | ENSG00000125798 |
| Varsome Browser | FOXA2 |
| Genetic variants : HAPMAP | 3170 |
| Genomic Variants (DGV) | FOXA2 [DGVbeta] |
| DECIPHER | FOXA2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOXA2 |
| Mutations |
|---|
| ICGC Data Portal | FOXA2 |
| TCGA Data Portal | FOXA2 |
| Broad Tumor Portal | FOXA2 |
| OASIS Portal | FOXA2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FOXA2 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | FOXA2 |
| Mutations and Diseases : HGMD | FOXA2 |
| intOGen Portal | FOXA2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FOXA2 |
| DgiDB (Drug Gene Interaction Database) | FOXA2 |
| DoCM (Curated mutations) | FOXA2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXA2 (select a term) |
| intoGen | FOXA2 |
| Cancer3D | FOXA2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600288 |
| Orphanet | |
| DisGeNET | FOXA2 |
| Medgen | FOXA2 |
| Genetic Testing Registry | FOXA2
|
| NextProt | Q9Y261 [Medical] |
| TSGene | 3170 |
| GENETests | FOXA2 |
| Target Validation | FOXA2 |
| Huge Navigator |
FOXA2 [HugePedia] |
| snp3D : Map Gene to Disease | 3170 |
| BioCentury BCIQ | FOXA2 |
| ClinGen | FOXA2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 3170 |
| Chemical/Pharm GKB Gene | PA201091 |
| Clinical trial | FOXA2 |
| Miscellaneous |
|---|
| canSAR (ICR) | FOXA2 (select the gene name) |
| DataMed Index | FOXA2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 136 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXA2 |
| EVEX | FOXA2 |
| GoPubMed | FOXA2 |
| iHOP | FOXA2 |
