FOXK1 (forkhead box K1)

2016-08-01  

Identity

HGNC
FOXK1
LOCATION
7p22.1
LOCUSID
221937
ALIAS
FOXK1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221937
MIM: 616302
HGNC: 23480
Ensembl: ENSG00000164916

Variants:

dbSNP: 221937
ClinVar: 221937
TCGA: ENSG00000164916
COSMIC: FOXK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164916ENST00000328914P85037
ENSG00000164916ENST00000460979U3KQ26

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
258051362015FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus.40
295504752018Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis.29
166248042006Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.25
278829392016Direct regulation of FOXK1 by C-jun promotes proliferation, invasion and metastasis in gastric cancer cells.22
281715952016Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.15
227406312012Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control.14
272230642016Oncogene FOXK1 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition.12
258521642015The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression.9
282674292017Knockdown of FOXK1 Suppresses Proliferation, Migration, and Invasion in Prostate Cancer Cells.8
307009092019FOXK1 and FOXK2 regulate aerobic glycolysis.8

Citation

Dessen P

FOXK1 (forkhead box K1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55896/foxk1