| Nomenclature |
|---|
| HGNC (Hugo) | FOXP2 13875 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FOXP2 93986 forkhead box P2 |
| Aliases | CAGH44; SPCH1; TNRC10 |
| GeneCards (Weizmann) | FOXP2 |
| Ensembl hg19 (Hinxton) | ENSG00000128573 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000128573 [Gene_View] ENSG00000128573 [Sequence] chr7:114414997-114693772 [Contig_View] FOXP2 [Vega] |
| ICGC DataPortal | ENSG00000128573 |
| TCGA cBioPortal | FOXP2 |
| AceView (NCBI) | FOXP2 |
| Genatlas (Paris) | FOXP2 |
| WikiGenes | 93986 |
| SOURCE (Princeton) | FOXP2 |
| Genetics Home Reference (NIH) | FOXP2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOXP2 - chr7:114414997-114693772 + 7q31.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOXP2 - 7q31.1 [Description] (hg19-Feb_2009) |
| GoldenPath | FOXP2 - 7q31.1 [CytoView hg19] FOXP2 - 7q31.1 [CytoView hg38] |
| ImmunoBase | ENSG00000128573 |
| Mapping of homologs : NCBI | FOXP2 [Mapview hg19] FOXP2 [Mapview hg38] |
| OMIM | 602081 605317 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF086040 AF337817 AF454830 AF467252 AF467253 |
| RefSeq transcript (Entrez) | NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOXP2 |
| Cluster EST : Unigene | Hs.282787 [ NCBI ] |
| CGAP (NCI) | Hs.282787 |
| Alternative Splicing Gallery | ENSG00000128573 |
| Gene Expression | FOXP2 [ NCBI-GEO ] FOXP2 [ EBI - ARRAY_EXPRESS ]
FOXP2 [ SEEK ] FOXP2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXP2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 93986 |
| GTEX Portal (Tissue expression) | FOXP2 |
| Human Protein Atlas | ENSG00000128573-FOXP2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15409 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15409 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15409 |
| Splice isoforms : SwissVar | O15409 |
| PhosPhoSitePlus | O15409 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) ZINC_FINGER_C2H2_1 (PS00028) |
| Domains : Interpro (EBI) | Fork_head_dom FOXP-CC TF_fork_head_CS_2 WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) FOXP-CC (PF16159) |
| Domain families : Pfam (NCBI) | pfam00250 pfam16159 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| Conserved Domain (NCBI) | FOXP2 |
| DMDM Disease mutations | 93986 |
| Blocks (Seattle) | FOXP2 |
| PDB (RSDB) | 2A07 2AS5 |
| PDB Europe | 2A07 2AS5 |
| PDB (PDBSum) | 2A07 2AS5 |
| PDB (IMB) | 2A07 2AS5 |
| Structural Biology KnowledgeBase | 2A07 2AS5 |
| SCOP (Structural Classification of Proteins) | 2A07 2AS5 |
| CATH (Classification of proteins structures) | 2A07 2AS5 |
| Superfamily | O15409 |
| Human Protein Atlas [tissue] | ENSG00000128573-FOXP2 [tissue] |
| Peptide Atlas | O15409 |
| HPRD | 05611 |
| IPI | IPI00940557 IPI00215632 IPI00383604 IPI00382947 IPI00454591 IPI00454592 IPI00879217 IPI00470950 IPI00784938 IPI00878144 IPI00288960 IPI00170880 IPI00853141 IPI00877946 IPI00877864 IPI00926273 IPI01008819 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15409 |
| IntAct (EBI) | O15409 |
| FunCoup | ENSG00000128573 |
| BioGRID | FOXP2 |
| STRING (EMBL) | FOXP2 |
| ZODIAC | FOXP2 |
| Ontologies - Pathways |
|---|
| QuickGO | O15409 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific positive regulation of mesenchymal cell proliferation DNA binding DNA-binding transcription factor activity protein binding nucleus skeletal muscle tissue development post-embryonic development cerebellum development caudate nucleus development putamen development cerebral cortex development response to testosterone vocal learning identical protein binding protein homodimerization activity camera-type eye development sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity lung alveolus development smooth muscle tissue development androgen receptor binding righting reflex positive regulation of epithelial cell proliferation involved in lung morphogenesis innate vocalization behavior |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific positive regulation of mesenchymal cell proliferation DNA binding DNA-binding transcription factor activity protein binding nucleus skeletal muscle tissue development post-embryonic development cerebellum development caudate nucleus development putamen development cerebral cortex development response to testosterone vocal learning identical protein binding protein homodimerization activity camera-type eye development sequence-specific DNA binding negative regulation of transcription, DNA-templated metal ion binding protein heterodimerization activity lung alveolus development smooth muscle tissue development androgen receptor binding righting reflex positive regulation of epithelial cell proliferation involved in lung morphogenesis innate vocalization behavior |
| NDEx Network | FOXP2 |
| Atlas of Cancer Signalling Network | FOXP2 |
| Wikipedia pathways | FOXP2 |
| Orthology - Evolution |
|---|
| OrthoDB | 93986 |
| GeneTree (enSembl) | ENSG00000128573 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXP2 |
| HOGENOM | O15409 |
| Homologs : HomoloGene | FOXP2 |
| Homology/Alignments : Family Browser (UCSC) | FOXP2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | COG5/FOXP2 [7q22.3/7q31.1] [t(7;7)(q31;q31)] |
| Fusion Portal | COG5 7q22.3 FOXP2 7q31.1 BRCA |
| Fusion Cancer (Beijing) | SFTPB [2p11.2] - FOXP2 [7q31.1] [FUSC003657] |
| Fusion : Quiver | FOXP2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOXP2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXP2 |
| dbVar | FOXP2 |
| ClinVar | FOXP2 |
| 1000_Genomes | FOXP2 |
| Exome Variant Server | FOXP2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000128573 |
| GNOMAD Browser | ENSG00000128573 |
| Varsome Browser | FOXP2 |
| Genetic variants : HAPMAP | 93986 |
| Genomic Variants (DGV) | FOXP2 [DGVbeta] |
| DECIPHER | FOXP2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOXP2 |
| Mutations |
|---|
| ICGC Data Portal | FOXP2 |
| TCGA Data Portal | FOXP2 |
| Broad Tumor Portal | FOXP2 |
| OASIS Portal | FOXP2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FOXP2 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | FOXP2 |
| Mutations and Diseases : HGMD | FOXP2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FOXP2 |
| DgiDB (Drug Gene Interaction Database) | FOXP2 |
| DoCM (Curated mutations) | FOXP2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXP2 (select a term) |
| intoGen | FOXP2 |
| Cancer3D | FOXP2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602081 605317 |
| Orphanet | 19612 18667 |
| DisGeNET | FOXP2 |
| Medgen | FOXP2 |
| Genetic Testing Registry | FOXP2
|
| NextProt | O15409 [Medical] |
| TSGene | 93986 |
| GENETests | FOXP2 |
| Target Validation | FOXP2 |
| Huge Navigator |
FOXP2 [HugePedia] |
| snp3D : Map Gene to Disease | 93986 |
| BioCentury BCIQ | FOXP2 |
| ClinGen | FOXP2 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 93986 |
| Chemical/Pharm GKB Gene | PA28242 |
| Clinical trial | FOXP2 |
| Miscellaneous |
|---|
| canSAR (ICR) | FOXP2 (select the gene name) |
| DataMed Index | FOXP2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 141 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXP2 |
| EVEX | FOXP2 |
| GoPubMed | FOXP2 |
| iHOP | FOXP2 |
